21597-54-6Relevant articles and documents
Improving the fluorescent probe acridonylalanine through a combination of theory and experiment
Sungwienwong, Itthipol,Ferrie, John J.,Jun, Joomyung V.,Liu, Chunxiao,Barrett, Taylor M.,Hostetler, Zachary M.,Ieda, Naoya,Hendricks, Amara,Muthusamy, Anand K.,Kohli, Rahul M.,Chenoweth, David M.,Petersson, George A.,Petersson, E. James
, (2018)
Acridonylalanine (Acd) is a useful fluorophore for studying proteins by fluorescence spectroscopy, but it can potentially be improved by being made longer wavelength or brighter. Here, we report the synthesis of Acd core derivatives and their photophysical characterization. We also performed ab initio calculations of the absorption and emission spectra of Acd derivatives, which agree well with experimental measurements. The amino acid aminoacridonylalanine (Aad) was synthesized in forms appropriate for genetic incorporation and peptide synthesis. We show that Aad is a superior F?rster resonance energy transfer acceptor to Acd in a peptide cleavage assay and that Aad can be activated by an aminoacyl tRNA synthetase for genetic incorporation. Together, these results show that we can use computation to design enhanced Acd derivatives, which can be used in peptides and proteins.
Chiroptical sensing of amino acids by stereodynamic imprinting into the ZnII-Complex generating a dihedral chirality
Chen, Qian,Shirbhate, Mukesh Eknath,Kim, Youngmee,Kim, Sung-Jin,Kang, Baotao,Kim, Kwan Mook
, p. 227 - 232 (2019)
A stereodynamic chiroptical sensor based on three-component assembly of 3-(di-2-picolylaminoacetamido)-2-formyl-naphthalene (1), ZnII and amino acids was developed. The imine formed between 1 and an amino acid has six coordination sites to bind
Fused cyclic compound and organoelectroluminescent device comprising the compound
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Paragraph 0145-0151, (2019/08/30)
PURPOSE: A condensed cyclic compound is provided to drive an organic electroluminescent device at low voltage and to improve brightness and economic efficiency. CONSTITUTION: A condensed cyclic compound is denoted by chemical formula 1. An organic electroluminescence device comprises an anode, a cathode, and a layer containing the condensed cyclic compounds, placed between the anode and the cathode. A light emitting layer between the anode and the cathode contains the condensed cyclic compounds. The organic electroluminescent device further comprises one or more layers selected among a hole injection layer, a hole transport layer, an electron blocking layer, a hole blocking layer, an electron transport layer, and an electron injection layer.