216249-59-1

Basic information

• Product Name: (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride
• Synonyms: (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride
• CAS NO: 216249-59-1
• Molecular Weight: 313.251
• Mol File: 216249-59-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride(216249-59-1)
• EPA Substance Registry System: (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride(216249-59-1)

Safety Data

• Hazardous Substances Data: 216249-59-1(Hazardous Substances Data)

Upstream product

• 216252-27-6 (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile 

Downstream Products

• 444728-17-0 (S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile 

Relevant articles and documents

PREPARATION OF (S)-CLOPIDOGREL AND RELATED COMPOUNDS

A process for producing enantiomerically enriched (S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrocarbyl ester, represented by the formula: Is provided, wherein R1 and R2 are hydrogens and R3 is methyl (i.e., (S)-Clopidogrel). The process includes the steps of: (a) contacting N-2-chlorobenz-aldehyde-ylidene-1-ethylamine-2(2-thiophenyl)imine and an HCN source, in the presence of a non-metallic asymmetric Strecker catalyst to form enantiomerically enriched (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile; (b) contacting the enantiomerically enriched (S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile and a formaldehyde equivalent, in the presence of an acid catalyst to form enantiomerically enriched α-5(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorobenzyl)-nitrile; and (c) contacting the enantiomerically enriched α-5(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorobenzyl)-nitrile and a reagent capable of converting a cyano group into an ester group to form enantiomerically enriched hydrocarbyl ester of (S)-α-(2-chlorophenyl)-6,7-dihydrothieno-[3,2-c]pyridine-5(4H)-acetic acid.