216311-67-0

Basic information

• Product Name: (3S)-2-(1-Benzylpyrrolidin-3-yl)acetic acid
• CAS NO: 216311-67-0
• Molecular Weight: 219.283
• Mol File: 216311-67-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S)-2-(1-Benzylpyrrolidin-3-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-2-(1-Benzylpyrrolidin-3-yl)acetic acid(216311-67-0)
• EPA Substance Registry System: (3S)-2-(1-Benzylpyrrolidin-3-yl)acetic acid(216311-67-0)

Safety Data

• Hazardous Substances Data: 216311-67-0(Hazardous Substances Data)

Upstream product

• 216311-63-6 2-((S)-1-Benzyl-pyrrolidin-3-yl)-malonic acid diethyl ester 
• 908598-98-1 (R)-2-Dibenzylamino-butane-1,4-diol 
• 118354-71-5 (S)-methanesulfonic acid 1-benzylpyrrolidin-3-yl ester 
• 216311-65-8 Ethyl (3S)-2-(1-benzylpyrrolidin-3-yl)acetate 

Downstream Products

• 122442-02-8 (S)-(+)-homo-β-proline 

Relevant articles and documents

A practical ex-chiral-pool synthesis of β-proline and homo-β-proline

Starting from aspartic acid an efficient synthesis of enantiomerically pure β-proline and homo-β-proline is described. The key step of the synthesis includes formation of the 1,4-biselectrophile 6, followed by rearrangement via the aziridinium intermediate 7 and ring closure to give the pyrrolidinium salt 9a which can serve as a common precursor for both target compounds.