21646-99-1 Usage
Description
TETRAETHYL PYROPHOSPHITE is a clear colorless liquid that serves as a versatile reagent in the field of organic chemistry. It is particularly known for its applications in the preparation of peptides and the phosphonylation of carbonyl compounds, making it a valuable tool for researchers and chemists.
Uses
Used in Organic Chemistry:
TETRAETHYL PYROPHOSPHITE is used as a reagent for peptide synthesis, playing a crucial role in the formation and modification of peptide bonds. This application is significant in the development of new pharmaceuticals and the study of protein structures.
Used in the Preparation of Peptides:
TETRAETHYL PYROPHOSPHITE is utilized in the preparation of peptides, where it aids in the formation of peptide bonds between amino acid residues. This process is essential for the synthesis of various peptides and proteins, which have potential applications in medicine, biotechnology, and other related fields.
Used in the Phosphonylation of Carbonyl Compounds:
In addition to its role in peptide synthesis, TETRAETHYL PYROPHOSPHITE is also used in the phosphonylation of carbonyl compounds. This reaction is important for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Overall, TETRAETHYL PYROPHOSPHITE is a valuable reagent in the fields of organic chemistry, pharmaceuticals, and biotechnology, thanks to its diverse applications in peptide synthesis and the modification of carbonyl compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 21646-99-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,4 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21646-99:
(7*2)+(6*1)+(5*6)+(4*4)+(3*6)+(2*9)+(1*9)=111
111 % 10 = 1
So 21646-99-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H20O5P2/c1-5-9-14(10-6-2)13-15(11-7-3)12-8-4/h5-8H2,1-4H3
21646-99-1Relevant articles and documents
Samuel,Silver
, p. 1155 (1963)
Reaction of (chloromethyl)phosphonic(-phosphinic) chlorides with silylated protic nucleophiles
Saakyan
, p. 1712 - 1716 (2007/10/03)
Reactions of (chloromethyl)phosphonic(-hosphinic) chlorides with trimethylalkoxy(-phenoxy, -dialkylamino)silanes are accompanied by elimination of trimethylchlorosilane and lead to formation of related substitution products. Reactions of bis(chloromethyl)phosphinic chloride and (chloromethyl)phosphinic dichloride with neutral and hydrogen silyl phosphites were studied. The reactions of bis(chloromethyl)phosphinic chloride with tris(trimethylsilyl)phosphite, diethyl trimethylsilyl phosphite, and bis(trimethylsilyl) hydrogen phosphite yield trimethylsilyl bis(chloromethyl)phosphinate. Similar reactions with (chloromethyl)phosphonic dichloride resulted in isolation of bis(trimethylsilyl) (chloromethyl)phosphonate.
Free-Radical Phosphorylation of Olefins Initiated by Anodic Oxidation
Romakhin,Kosachev,Zagumennov,Nikitin
, p. 227 - 234 (2007/10/03)
Electrochemical oxidation of lithium and sodium dialkyl phosphites generates dialkyl phosphonyl radicals, which initiate chain free-radical addition of dialkyl phosphites across the alkene multiple bond to form alkyl(cycloalkyl)phosphonates. Alkyl(cycloalkyl)phosphonates are formed simultaneously owing to anodic oxidation of adsorbed primary radical adducts of phosphonyl radical and alkene molecule to give the carbenium cation, followed by deprotonation of the latter.
