216755-57-6

Basic information

• Product Name: 3-Fluoro-5-bromobenzyl bromide
• Synonyms: 3-Fluoro-5-bromobenzyl bromide;5-bromo-3-fluorobenzyl bromide;1-Bromo-3-(bromomethyl)-5-fluorobenzene;3-Fluoro-5-broMobenl broMide;1-Bromo-3-(bromomethyl)-5-fluorobenzene, alpha,3-Dibromo-5-fluorotoluene;3-Fluoro-5-bromoben bromide
• CAS NO: 216755-57-6
• Molecular Formula: C₇H₅Br₂F
• Molecular Weight: 267.93
• Product Categories: Fluorine series;alkyl bromide| alkyl Fluorine
• Mol File: 216755-57-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 47 °C
• Boiling Point: 251℃
• Flash Point: 106℃
• Appearance: /
• Density: 1.923
• Vapor Pressure: 0.033mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: soluble in Methanol
• Water Solubility: Slightly soluble in water (2.9 g/L) (25°C).
• Sensitive: Lachrymatory
• CAS DataBase Reference: 3-Fluoro-5-bromobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-5-bromobenzyl bromide(216755-57-6)
• EPA Substance Registry System: 3-Fluoro-5-bromobenzyl bromide(216755-57-6)

Safety Data

• Hazard Codes: C,T
• Statements: 25
• Safety Statements: 45
• HazardClass: 8
• Hazardous Substances Data: 216755-57-6(Hazardous Substances Data)

Usage

Uses

3-Bromo-5-fluorobenzyl bromide is employed as a intermediate for pharmaceutical and chemical research.

InChI:InChI=1/C7H5Br2F/c8-4-5-1-6(9)3-7(10)2-5/h1-3H,4H2

Upstream product

• 216755-56-5 5-fluoro-3-hydroxymethylbromobenzene 
• 202865-83-6 1-bromo-3-fluoro-5-methylbenzene 
• 176548-70-2 3-bromo-5-fluorobenzoic acid 

Downstream Products

• 1192039-98-7 tert-butyl 1-(3-bromo-5-fluorobenzyl)-cyclopropanecarboxylate 
• 1192040-04-2 tert-butyl 1-[3-(benzylamino)-5-fluorobenzyl]-cyclopropanecarboxylate 
• 1192040-10-0 tert-butyl 1-(3-amino-5-fluorobenzyl)-cyclopropanecarboxylate 

Relevant articles and documents

Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17)

The synthesis of steroid hormones is critical to human physiology and improper regulation of either the synthesis of these key molecules or activation of the associated receptors can lead to disease states. This has led to intense interest in developing c

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS

The present invention concerns the use of compounds for preventing and/or treating osteoporosis, for stimulating bone formation, for stimulating bone remodeling, for stimulating the differentiation and mineralization of osteoblasts, for inhibiting bone resorption and for modulating serum level of adiponectin in a subject. These uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts thereof. wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is H, F, OH, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F, or OH; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(F)-C(O)OH, 3) CF2-C(O)OH or 4) C(O)-C(O)OH.

2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives of formula (I) wherein Ar1, Q, and R1 to R5 are as described in the description, to their preparation, to