21676-90-4 Usage
Description
Methyl 4-phenylthiophene-2-carboxylate is a chemical compound with the molecular formula C13H10O2S. It is an ester derivative of phenylthiophene carboxylic acid and is often used as an intermediate in the synthesis of various organic compounds. It is a yellow to brown crystalline powder and is commonly used in pharmaceutical and agrochemical research. Methyl 4-phenylthiophene-2-carboxylate is known for its wide range of applications in the field of organic chemistry and is valued for its potential as a building block in the creation of new and innovative molecules.
Uses
Used in Pharmaceutical Research:
Methyl 4-phenylthiophene-2-carboxylate is used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason].
Used in Agrochemical Research:
Methyl 4-phenylthiophene-2-carboxylate is used as an intermediate in the synthesis of various agrochemical compounds for [application reason].
Used in Organic Chemistry:
Methyl 4-phenylthiophene-2-carboxylate is used as a building block in the creation of new and innovative molecules for [application reason].
Check Digit Verification of cas no
The CAS Registry Mumber 21676-90-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,7 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21676-90:
(7*2)+(6*1)+(5*6)+(4*7)+(3*6)+(2*9)+(1*0)=114
114 % 10 = 4
So 21676-90-4 is a valid CAS Registry Number.
21676-90-4Relevant articles and documents
Ag(I)-Catalyzed C-H Carboxylation of Thiophene Derivatives
Lee, Mijung,Hwang, Young Kyu,Kwak, Jaesung
supporting information, p. 3136 - 3144 (2021/09/30)
CO2utilization is an attractive aspect as it allows the direct conversion of CO2into valuable chemicals. In this regard, direct incorporation of CO2into the C-H bond of heteroaromatic compounds is important due to the ubiquitous structural motifs of the heteroaromatic carboxylic acids. Herein, we report the Ag-catalyzed C-H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithiumtert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. Experimental studies revealed that the use oftert-butyl alkoxide is critical for the exergonic formation of an arylsilver intermediate, and the results were further supported by density functional theory calculations.
In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides
Milner, Phillip J.,Yang, Yang,Buchwald, Stephen L.
supporting information, p. 4775 - 4780 (2015/10/28)
A thorough investigation of the challenging Pd-catalyzed fluorination of five-membered heteroaryl bromides is presented. Crystallographic studies and density functional theory (DFT) calculations suggest that the challenging step of this transformation is
3-alkyl or aryl thiophenes from malonaldehyde derivatives
Kirsch,Prim
, p. 1721 - 1726 (2007/10/02)
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