217189-04-3

Basic information

• Product Name: (4-PYRID-3-YLPHENYL)METHANOL
• Synonyms: 4-(5-Chloropyridin-3-yl)benzyl alcohol;4-(5-Fluoropyridin-3-yl)benzyl alcohol;4-(5-Hydroxypyridin-3-yl)benzyl alcohol;4-(6-Chloropyridin-3-yl)benzyl alcohol;4-(6-Fluoropyridin-3-yl)benzyl alcohol;4-(6-Hydroxypyridin-3-yl)benzyl alcohol;4-(Pyridin-3-yl)benzyl alcohol;3-[4-(Hydroxymethyl)phenyl]pyridine97%
• CAS NO: 217189-04-3
• Molecular Formula: C12H11NO
• Molecular Weight: 185.22
• Product Categories: pharmacetical
• Mol File: 217189-04-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 105.5-107.5
• Boiling Point: 363.9 °C at 760 mmHg
• Flash Point: 173.9 °C
• Appearance: /
• Density: 1.145g/cm³
• Vapor Pressure: 6.19E-06mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: 2-8°C
• PKA: 14.14±0.10(Predicted)
• CAS DataBase Reference: (4-PYRID-3-YLPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-PYRID-3-YLPHENYL)METHANOL(217189-04-3)
• EPA Substance Registry System: (4-PYRID-3-YLPHENYL)METHANOL(217189-04-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 217189-04-3(Hazardous Substances Data)

Usage

General Description

(4-Pyrid-3-ylphenyl)methanol is a chemical compound with the molecular formula C13H11NO. It is a pale yellow solid that is mainly used in research and pharmaceutical applications. Its structure consists of a pyridine ring attached to a phenyl ring, with a hydroxyl group attached to the phenyl group. (4-PYRID-3-YLPHENYL)METHANOL can be used as a building block in the synthesis of various organic compounds and pharmaceuticals due to its unique structure and reactivity. It has potential applications in drug discovery and material science. Additionally, it is important to handle this compound with care as it can be potentially hazardous if not properly handled and stored.

InChI:InChI=1/C12H11NO/c14-9-10-3-5-11(6-4-10)12-2-1-7-13-8-12/h1-8,14H,9H2

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 1692-25-7 3-pyridylboronic acid 
• 329214-79-1 3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Relevant articles and documents

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS

This invention is directed to an (aminoiminomethyl or aminomethyl) benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.