217806-26-3 Usage
General Description
Tert-Butyl (azetidin-3-yl)carbamate hydrochloride is a chemical compound that is the hydrochloride salt form of tert-Butyl (azetidin-3-yl)carbamate. It is a carbamate derivative with potential antineoplastic activity. tert-Butyl (azetidin-3-yl)carbamate hydrochloride may inhibit the proliferation of cancer cells by targeting key enzymes involved in cell growth and proliferation pathways. Additionally, it may also have potential applications in other areas of medicine, such as in the treatment of neurological disorders and infectious diseases. Further research is needed to fully understand its pharmacological properties and potential therapeutic uses.
Check Digit Verification of cas no
The CAS Registry Mumber 217806-26-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,7,8,0 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 217806-26:
(8*2)+(7*1)+(6*7)+(5*8)+(4*0)+(3*6)+(2*2)+(1*6)=133
133 % 10 = 3
So 217806-26-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H16N2O2/c1-8(2,3)12-7(11)10-6-4-9-5-6/h6,9H,4-5H2,1-3H3,(H,10,11)
217806-26-3Relevant articles and documents
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet-Spengler Condensation
Chung, Cheol K.,Clagg, Kyle,Dalziel, Michael E.,Fettes, Alec,Finet, Laure,Gosselin, Francis,Jenny, Christian,Kammerer, Michael,Lim, Ngiap-Kie,Mack, Kyle A.,McClory, Andrew,Wuitschik, Georg,Xu, Jie,Zhang, Haiming,Angelaud, Rémy
, (2021/11/24)
GDC-9545 is a selective estrogen receptor degrader that is being developed as a treatment for ER+/HER2- breast cancer. A robust, convergent manufacturing process for GDC-9545 was developed. The process features a Wenker aziridine synthesis to produce the key starting material tryptamine 11, a highly efficient C-N coupling between aminoazetidine 9 and 2,6-difluoro-4-bromobenzaldehyde diethyl acetal (33) to construct key intermediate 10, and a crystallization-driven diastereoselective Pictet-Spengler reaction to furnish the active pharmaceutical ingredient GDC-9545·tartrate.
