21789-10-6Relevant articles and documents
Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors
Oza, Vibha B.,Smith, Craig,Raman, Prakash,Koepf, Edward K.,Lashuel, Hilal A.,Petrassi, H. Mike,Chiang, Kyle P.,Powers, Evan T.,Sachettinni, James,Kelly, Jeffery W.
, p. 321 - 332 (2002)
Twelve analogues of diclofenac (1), a nonsteroidal antiinflammatory drug and known inhibitor of transthyretin (TTR) amyloid formation, were prepared and evaluated as TTR amyloid formation inhibitors. High activity was exhibited by five of the compounds. S