2181-97-7

Basic information

• Product Name: CARBOMETHOXYMETHYL TRIPHENYLPHOSPHONIUM CHLORIDE
• Synonyms: CARBOMETHOXYMETHYL-TRIPHENYLPHOSPHONIUMCHLORID;CARBOMETHOXYMETHYL TRIPHENYLPHOSPHONIUM CHLORIDE;(METHOXYCARBONYLMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE;(CARBOMETHOXYMETHYL)TRIPHENYLPHOSPHONIU&;methyl (triphenylphosphonio)acetate chloride;[(Methoxycarbonyl)methyl]triphenylphosphonium chloride, 97 %;(Carbomethoxymethyl)triphenylphosphonium chloride,97%;(2-Methoxy-2-oxoethyl)tris(phenyl)phosphonium chloride
• CAS NO: 2181-97-7
• Molecular Formula: C₂₁H₂₀O₂P*Cl
• Molecular Weight: 370.81
• EINECS: -0
• Mol File: 2181-97-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 155 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /solid
• Density: g/cm³
• Storage Temp.: 0-6°C
• Water Solubility: Very Soluble in water (100 g/L) (25°C).
• Sensitive: Hygroscopic
• BRN: 4172737
• CAS DataBase Reference: CARBOMETHOXYMETHYL TRIPHENYLPHOSPHONIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CARBOMETHOXYMETHYL TRIPHENYLPHOSPHONIUM CHLORIDE(2181-97-7)
• EPA Substance Registry System: CARBOMETHOXYMETHYL TRIPHENYLPHOSPHONIUM CHLORIDE(2181-97-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36
• Hazardous Substances Data: 2181-97-7(Hazardous Substances Data)

Usage

Chemical Properties

white fine crystalline powder

Uses

It is employed as intermediate for pharmaceutical.

InChI:InChI=1/C21H20O2P.ClH/c1-23-21(22)17-24(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20;/h2-16H,17H2,1H3;1H/q+1;/p-1

Upstream product

• 96-34-4 methyl chloroacetate 
• 603-35-0 triphenylphosphine 
• 330475-99-5 (Ph₃PCH₂Ph)(PtCl₅(NH=C(Et)ON=C(C₅H₁₀))) 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 330475-97-3 (Ph₃PCH₂Ph)(PtCl₅(NH=C(Et)ON=C(C₄H₈))) 
• 330475-94-0 (Ph₃PCH₂Ph)(PtCl₅(NH=C(Et)ON=CMe₂)) 
• 245414-27-1 (PtCl₄(NHC(CH₃)ON(CH₂C₆H₅)2)2) 
• 218602-67-6 (PtCl₄(NHC(CH₃)ONC(CH₂)5)2) 
• 218602-66-5 (PtCl₄(NHC(CH₃)ONC(CH₂)4)2) 
• 259260-86-1 (PtCl₄(NHC(CH₃)ONC(CH₃)C(CH₃)NOH)2) 
• 270064-62-5 (PtCl₄(NC(CH₃)ON(CH₃)CHC₆H₅)2) 
• 245414-26-0 (PtCl₄(NHC(CH₃)ON(C₂H₅)2)2) 
• 337526-21-3 (PtCl₄(NH=C(Me)ON=CMeEt)2) 
• 218602-65-4 (PtCl₄(NHC(CH₃)ONC(CH₃)2)2) 

Downstream Products

• 54557-00-5 methyl 3-phenyl-3-oxo-2-(triphenylphosphoranylidene)propionate 
• 876914-41-9 tert-butyl (S,E)-2-(4-(octyloxy)phenylcarbamoyl)-4-(methoxycarbonyl)but-3-en-2-ylcarbamate 
• 40203-74-5 methyl 2-cyclohexylideneacetate 
• 54160-54-2 (Z)-2-(prop-1-en-3-methoxycarbonyl)furane 
• 58293-85-9 methyl 3-(2-furyl)acrylate 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 19310-29-3 3-(4-methoxyphenyl)acrylic acid methyl ester 
• 177649-93-3 [Ph3PCH2COOMe][PtCl3(η(2)-C2H4)] 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 105376-46-3 3-(2'-nitrophenyl)-(Z)-propenoic acid methyl ester 

Relevant articles and documents

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Reduction of (imine)Pt(IV) to (imine)Pt(II) complexes with carbonyl-stabilized phosphorus ylides

A novel method is reported for generation of the difficult-to-obtain (imine)Pt(II) compounds that involves reduction of the corresponding readily available Pt(IV)-based imines by carbonyl-stabilized phosphorus ylides, Ph3P= CHCO2R, in nonaqueous media. The reaction between neutral (imino)Pt(IV) compounds [PtCl4{NH=C(Me)-ON=CR1R2}2] [R1R2 = Me2, (CH2)4, (CH2)5, (Me)C(Me)=NOH], [PtCl4{NH=C(Me)ONR2}2] (R = Me, Et, CH2Ph), [PtCl4{N=C(Me)O-N(R3)-C(R1) (R2)}2] (R1 = H; R2 = Ph or C6H4Me; R3 = Me) as well as anionic-type platinum(IV) complexes (Ph3PCH2Ph)[PtCl5{NH=C(Me) ON=CR2}] [R2 = Me2, (CH2)4, (CH2)5] and 1 equiv of Ph3P=CHCO2R (R = Me, Et) proceeds under mild conditions (ca. 4 h, room temperature) to give selectively the platinum(II) products (in good to excellent isolated yields) without further reduction of the platinum center. All thus prepared compounds (excluding previously described Δ4-1,2,4-oxadiazoline complexes) were characterized by elemental analyses, FAB mass spectrometry, IR and 1H, 13C{1H}, 31P(1H} and 195Pt NMR spectroscopies, and X-ray single-crystal diffractometry, the latter for [PtCl2{NH=C(Me)ON=CMe2}2] [crystal system tetragonal, space group P42/n (No. 86), a = b = 10.5050(10) A, c = 15.916(3) A] and (Ph3PCH2CO2-Me)[PtCl3(NCMe)] [crystal system orthorhombic, space group Pna21 (No. 33), a = 19.661(7) A, b = 12.486(4) A, c = 10.149(3) A]. The reaction is also extended to a variety of other Pt(II)/Pt(IV) couples, and the ylides Ph3P=CHCO2R are introduced as mild and selective reducing agents of wide applicability for the conversion of Pt(IV) to Pt(II) species in nonaqueous media, a route that is especially useful in the case of compounds that cannot be prepared directly from Pt(II) precursors, and for the generation of systematic series of Pt(II)/Pt(IV) complexes for biological studies.

7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs

New 7-oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs which have the general formula STR1 wherein R1 is hydrogen or lower alkyl; n is 0 to 4, m is 0 to 4 and x is 0 to 8, are useful as cardiovascular agents.