218461-38-2Relevant articles and documents
Synthesis of 1-oxacephams via improved cyclization of N-substituted-4- formyloxyazetidin-2-ones
Kaluza, Zbigniew
, p. 8349 - 8352 (2007/10/03)
The Lewis acid promoted cyclisation of N-substituted-4- formyloxyazetidin-2-ones, easily available from 4-vinyloxyazetidin-2-one is described. The efficiency of the ring closure reaction, to give 1-oxacephams, depends on the oxygen protected-activated group and the Lewis acid.