21900-42-5

Basic information

• Product Name: 2,4-DIMETHYLBENZOYL CHLORIDE
• Synonyms: BUTTPARK 48\06-96;Benzoyl chloride, 2,4-dimethyl- (6CI,8CI,9CI);Benzoyl chloride, 2,4-dimethyl-;4-(Chlorocarbonyl)-m-xylene, 4-(Chloroformyl)-m-xylene;2,4-DIMETHYLBENZOYL CHLORIDE
• CAS NO: 21900-42-5
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.62
• Product Categories: ACIDHALIDE
• Mol File: 21900-42-5.mol
• Article Data: 43

Chemical Properties

• Melting Point: 24-26℃
• Boiling Point: 122°C/10mm
• Flash Point: 103℃
• Appearance: /
• Density: 1.136
• Vapor Pressure: 0.0513mmHg at 25°C
• Refractive Index: 1.5480 (estimate)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2,4-DIMETHYLBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYLBENZOYL CHLORIDE(21900-42-5)
• EPA Substance Registry System: 2,4-DIMETHYLBENZOYL CHLORIDE(21900-42-5)

Safety Data

• Hazard Codes: C,Xi
• Statements: 36
• Safety Statements: 26
• RIDADR: UN3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 21900-42-5(Hazardous Substances Data)

Usage

General Description

2,4-Dimethylbenzoyl chloride, also known as 2,4-DMBC, is a chemical compound with the molecular formula C9H9ClO. It is a colorless to pale yellow liquid that is primarily used in the production of pharmaceuticals and agrochemicals. 2,4-DIMETHYLBENZOYL CHLORIDE is an acyl chloride and is synthesized through the reaction of 2,4-dimethylbenzoic acid with thionyl chloride. It is a highly reactive compound and is used as a building block in the synthesis of various chemicals and materials. It is known to be a strong irritant to the skin, eyes, and respiratory system, and therefore should be handled with caution and in accordance with proper safety measures.

InChI:InChI=1/C9H9ClO/c1-6-3-4-8(9(10)11)7(2)5-6/h3-5H,1-2H3

Upstream product

• 108-38-3 m-xylene 
• 79-37-8 oxalyl dichloride 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 201230-82-2 carbon monoxide 
• 583-70-0 1-bromo-2,4-dimethylbenzene 
• 89-74-7 2,4-dimethylacetophenone. 
• 75-44-5 phosgene 
• 7446-70-0 aluminium trichloride 
• 3416-93-1 2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline 

Downstream Products

• 93151-41-8 2,4-dimethyl-benzoic acid-(2-diethylamino-ethylamide) 
• 5180-83-6 2,4-dimethyl-benzoic acid anilide 
• 23617-71-2 2,4-dimethyl-benzoic acid methyl ester 
• 859190-87-7 (2,4-dimethyl-phenyl)-(5,6,7,8-tetrahydro-[2]naphthyl)-ketone 
• 857535-27-4 2,4-dimethyl-benzoic acid-(N-methyl-2-nitro-anilide) 
• 51725-81-6 3-(2,4-dimethyl-phenyl)-3-oxo-propionic acid ethyl ester 
• 74733-28-1 methyl 4-(bromomethyl)-2-methylbenzoate 
• 622847-32-9 2-bromomethyl-4-methylbenzoic acid methyl ester 
• 861555-51-3 2-bromomethyl-4-methyl-benzoyl bromide 
• 861555-49-9 2,4-bis-dichloromethyl-benzoyl chloride 
• 861522-57-8 2,4-bis-bromomethyl-benzoyl bromide 
• 622367-70-8 2,4-bis-trichloromethyl-benzoyl chloride 
• 94373-54-3 2,4-dimethyl-N-(3-morpholin-4-yl-propyl)-benzamide 
• 93142-41-7 2,4-dimethyl-N-(1-methyl-2-morpholin-4-yl-ethyl)-benzamide 

Relevant articles and documents

Pd(II)-catalyzed annulation reactions of epoxides with benzamides to synthesize isoquinolones

Epoxides as alkylating reagents are unprecedentedly applied in Pd(II)-catalyzed C?H alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones rather than isochromans, which is accomplished through alerting the previously reported reaction mechanism by the addition of oxidant and TEA. Under these conditions, various isoquinolones have been prepared with yields up to 92%. In addition, this methodology has been successfully employed in the total syntheses of rupreschstyril, siamine, and cassiarin A in an expedient fashion.

Development of AC265347-Inspired Calcium-Sensing Receptor Ago-Positive Allosteric Modulators

The calcium-sensing receptor (CaSR) is a clinical target in the treatment of hyperparathyroidism and related diseases. However, clinical use of approved CaSR-targeting drugs such as cinacalcet is limited due to adverse side effects including hypocalcaemia

Electrodimerization ofN-Alkoxyamides for the Synthesis of Hydrazines

An efficient and valuable N-N dimerization reaction ofN-alkoxyamides is reported under undivided electrolytic conditions. This electrochemical strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines. Remarkably, anN-centered radical generated from the cleavage of the N-H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, variousN-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.