21900-51-6

Basic information

• Product Name: 2-CHLORO-5-FLUOROBENZOYL CHLORIDE
• Synonyms: 2-CHLORO-5-FLUOROBENZOYL CHLORIDE;5-FLUORO-2-CHLOROBENZOYL CHLORIDE;2-Chloro-5-fluorobenzoyl chloride, 97+%;Benzoyl chloride, 2-chloro-5-fluoro- (8CI,9CI);2-Chloro-5-fluorobenzoyl chloride 98%;2-Chloro-5-fluorobenzoylchloride98%;2-(Chlorocarbonyl)-4-fluorochlorobenzene
• CAS NO: 21900-51-6
• Molecular Formula: C₇H₃Cl₂FO
• Molecular Weight: 193
• EINECS: -0
• Product Categories: ACIDHALIDE
• Mol File: 21900-51-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 79～82℃
• Boiling Point: 106/18mm
• Flash Point: 106°C/18mm
• Appearance: /
• Density: 1.462g/cm³
• Vapor Pressure: 0.0783mmHg at 25°C
• Refractive Index: 1.55
• Sensitive: Moisture Sensitive
• BRN: 2640754
• CAS DataBase Reference: 2-CHLORO-5-FLUOROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-FLUOROBENZOYL CHLORIDE(21900-51-6)
• EPA Substance Registry System: 2-CHLORO-5-FLUOROBENZOYL CHLORIDE(21900-51-6)

Safety Data

• Hazard Codes: C,Xn
• Statements: 34-22
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 21900-51-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-fluorobenzoyl chloride is an organic chemical compound with the molecular formula C7H3Cl2FO. It is a benzoyl chloride derivative, featuring chloro and fluoro substituents at the 2- and 5- positions, respectively, of the benzene ring. 2-CHLORO-5-FLUOROBENZOYL CHLORIDE is a reactive intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals, as it can undergo various chemical reactions, such as acylation, amidation, and esterification. It is also used as a building block in the production of dyes, pigments, and other specialty chemicals. However, it should be handled with care, as it is corrosive and can cause severe skin and eye irritation upon contact.

InChI:InChI=1/C7H3Cl2FO/c8-6-2-1-4(10)3-5(6)7(9)11/h1-3H

Upstream product

• 2252-50-8 2-chloro-5-fluoro-benzoic acid 

Downstream Products

• 1130037-51-2 [carboxy-14C]4-(2-chloro-5-fluorobenzoylamino)-3-methoxybenzoic acid 
• 1256846-68-0 2-chloro-N-benzyl-5-fluorobenzamide 
• 1456616-38-8 C₁₂H₉ClFNO₃ 
• 1456616-34-4 C₈H₅ClFNO₃ 

Relevant articles and documents

A highly efficient copper-catalyzed method for the synthesis of 2-hydroxybenzamides in water

An efficient copper-catalyzed synthetic method for the preparation of 2-hydroxybenzamides is described for the first time from 2-chlorobenzamide substrates using copper iodide/1,10-phenanthroline and a base, potassium hydroxide, in neat water. By using this reaction, a series of 2-hydroxybenzamides with functional groups such as fluoro, chloro, iodo, methoxy, amide, and alcohol have been obtained in 33-96% yield. Other aromatic 2-chloroarylamides such as naphthalene, pyridine, and thiophene are found to be equally compatible to the reaction. It is proposed that the reaction proceed via formation of copper-amide complex, which may facilitate the hydroxylation in water. Overall, the first report on copper-catalyzed hydroxylation reaction in water and first catalytic route for the synthesis of 2-hydroxybenzamides is presented. Simple purification procedure and convenience of employing low-cost reagents in neat water make this method practical and economical for the synthesis of 2-hydroxybenzamides. Georg Thieme Verlag Stuttgart · New York.

SPIROBENZOAZEPANES AS VASOPRESSIN ANTAGONISTS

The present invention is directed to a compound of Formula (I) or a form thereof: wherein U, V, W and Ring A are as defined herein, useful as vasopressin receptor antagonists.