21911-66-0

Basic information

• Product Name: ethyl 2-[(3-methylphenyl)amino]acetate
• Synonyms: ethyl 2-[(3-methylphenyl)amino]acetate;ETHYL 3-TOLUIDINOACETATE
• CAS NO: 21911-66-0
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.245
• Mol File: 21911-66-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 293.2 °C at 760 mmHg
• Flash Point: 131.1 °C
• Appearance: /
• Density: 1.084 g/cm³
• Vapor Pressure: 0.00175mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: ethyl 2-[(3-methylphenyl)amino]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(3-methylphenyl)amino]acetate(21911-66-0)
• EPA Substance Registry System: ethyl 2-[(3-methylphenyl)amino]acetate(21911-66-0)

Safety Data

• Hazardous Substances Data: 21911-66-0(Hazardous Substances Data)

Usage

General Description

Ethyl 2-[(3-methylphenyl)amino]acetate is a chemical compound with the molecular formula C11H15NO2. It is an ester derivative of amino acid and is commonly used in the production of pharmaceuticals and organic compounds. ethyl 2-[(3-methylphenyl)amino]acetate is typically used as an intermediate compound in the synthesis of various substances, such as drugs, dyes, and perfumes. It is also used in organic chemistry research for the development of new chemicals and materials. Ethyl 2-[(3-methylphenyl)amino]acetate is a colorless liquid with a slight odor and is considered to be a relatively stable and non-hazardous compound when handled and stored properly.

InChI:InChI=1/C11H15NO2/c1-3-14-11(13)8-12-10-6-4-5-9(2)7-10/h4-7,12H,3,8H2,1-2H3

Upstream product

• 60-29-7 diethyl ether 
• 105-39-5 chloroacetic acid ethyl ester 
• 108-44-1 1-amino-3-methylbenzene 
• 623-73-4 diazoacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1263063-59-7 ethyl 2-(3-methylphenylamino)-4-oxopentanoate 
• 74283-75-3 bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester 
• 3483-17-8 N-(3-methylphenyl)sydnone 
• 21911-67-1 N-(m-methylphenyl)glycine 

Relevant articles and documents

Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of α-diazo esters into the N-H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

Exploiting Synergistic Catalysis for an Ambient Temperature Photocycloaddition to Pyrazoles

Sydnone-based cycloaddition reactions are a versatile platform for pyrazole synthesis, however they operate under harsh conditions (high temperature and long reaction times). Herein we report a strategy that addresses this limitation utilizing the synergistic combination of organocatalysis and visible-light photocatalysis. This new approach proceeds under ambient conditions and with excellent levels of regiocontrol. Mechanistic studies suggest that photoactivation of sydnones, rather than enamines, is key to the successful implementation of this process.

CATHEPSIN-D AND ANGIOGENESIS INHIBITORS AND COMPOSITIONS THEREOF FOR TREATING BREAST CANCER

The invention relates to Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer. More particularly, the invention relates to the design and synthesis of inhibitors of Cathepsin D which exhibits antiproliferative activity and also inhibits angiogenesis. The present invention also relates to the compositions thereof for treating breast cancer.