219719-95-6

Basic information

• Product Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione
• Synonyms: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione;Fluticasone Related CoMpound B;Fluticasone USP RC B;6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-2',3,4'-trioxo-17alpha-spiro(androsta-1,4-diene-17,5'-(1,3)oxathiolane)
• CAS NO: 219719-95-6
• Molecular Formula: C22H24F2O5S
• Molecular Weight: 438.4847664
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 219719-95-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 562.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 12.93±0.70(Predicted)
• CAS DataBase Reference: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione(CAS DataBase Reference)
• NIST Chemistry Reference: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione(219719-95-6)
• EPA Substance Registry System: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione(219719-95-6)

Safety Data

• Hazardous Substances Data: 219719-95-6(Hazardous Substances Data)

Usage

Description

6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-2',3,4'-trioxo-17alpha-spiro(androsta-1,4-diene-17,5'-(1,3)oxathiolane) is a complex organic compound with a unique molecular structure. It is characterized by the presence of fluorine atoms at the 6alpha and 9alpha positions, a hydroxyl group at the 11beta position, and a methyl group at the 16alpha position. The molecule also features a spiro connection between the androsta-1,4-diene and the 1,3-oxathiolane rings, with additional oxygen atoms at the 2', 3, and 4' positions. 6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-2',3,4'-trioxo-17alpha-spiro(androsta-1,4-diene-17,5'-(1,3)oxathiolane) is an impurity of Fluticasone Propionate (F599500) and a derivative of Flumethasone (F455000), which are corticosteroids used in the treatment of various inflammatory conditions.

Uses

Used in Pharmaceutical Industry:
6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-2',3,4'-trioxo-17alpha-spiro(androsta-1,4-diene-17,5'-(1,3)oxathiolane) is used as an impurity in the production of Fluticasone Propionate (F599500) and Flumethasone (F455000) for their antiallergic, anti-asthmatic, and anti-inflammatory properties. These corticosteroids are widely used in the treatment of various respiratory, skin, and eye conditions, as well as other inflammatory disorders.
Used in Research and Development:
As an impurity of Fluticasone Propionate and a derivative of Flumethasone, this compound may also be used in research and development for the study of corticosteroid properties, their effects on the body, and the development of new drugs with improved efficacy and reduced side effects.
Used in Quality Control and Regulatory Compliance:
6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-2',3,4'-trioxo-17alpha-spiro(androsta-1,4-diene-17,5'-(1,3)oxathiolane) may be utilized in the quality control and regulatory compliance processes for pharmaceutical manufacturers. By monitoring the presence and concentration of this impurity in the final drug product, manufacturers can ensure the safety, efficacy, and quality of their corticosteroid medications.