2199-63-5

Basic information

• Product Name: 2,5-DIMETHYL-1H-PYRROLE-3-CARBALDEHYDE
• Synonyms: 2,5-dimethyl-1H-pyrrole-3-carbaldehyde(SALTDATA: FREE)
• CAS NO: 2199-63-5
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.16
• Mol File: 2199-63-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 251.2°Cat760mmHg
• Flash Point: 112.2°C
• Appearance: /
• Density: 1.099g/cm³
• Vapor Pressure: 0.0208mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2,5-DIMETHYL-1H-PYRROLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-1H-PYRROLE-3-CARBALDEHYDE(2199-63-5)
• EPA Substance Registry System: 2,5-DIMETHYL-1H-PYRROLE-3-CARBALDEHYDE(2199-63-5)

Safety Data

• Hazardous Substances Data: 2199-63-5(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHYL-1H-PYRROLE-3-CARBALDEHYDE is a chemical compound with the molecular formula C7H9NO. It is a heterocyclic aromatic compound that contains both a pyrrole ring and a carbonyl group. This chemical is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals, dyes, and other fine chemicals. Its structure and properties make it useful for the development of new drugs and materials. Additionally, it has potential applications in the field of organic electronics and as a starting material for the synthesis of complex organic molecules. Its unique structure and reactivity make it an important compound in the field of organic chemistry.

InChI:InChI=1/C7H9NO/c1-5-3-7(4-9)6(2)8-5/h3-4,8H,1-2H3

Upstream product

• 625-84-3 2,5-Dimethylpyrrole 
• 67-66-3 chloroform 
• 68-12-2 N,N-dimethyl-formamide 
• 97142-87-5 1-formyl-2,5-dimethyl-pyrrole 
• 1478-41-7 diethoxycarbonium fluoroborate 
• 109-94-4 formic acid ethyl ester 
• 231609-59-9 2-(2-cyano-1-methylvinylamino)-N-methoxy-N-methylpropionamide 
• 124647-48-9 N-(hydroxy-2' methyl-1' ethyl) amino-3 butene-2 oate d'ethyle 

Downstream Products

• 2406-14-6 2,5-dimethyl-pyrrole-3-carbaldehyde-(4-nitro-phenylhydrazone) 

Relevant articles and documents

Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic arylpyrrole-based chalcone derivatives

With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 μM, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.

Versatility of Weinreb amides in the Knorr pyrrole synthesis

N-Methoxy-N-methyl-α-enaminocarboxamides were prepared starting from enamines and Weinreb α-aminoamides. Their reaction with oganometallic compounds and subsequent cyclization constitute a versatile alternative in the Knorr pyrrole synthesis.

SYNTHESE DE PYRROLES ET D'OXAZOLES PAR PYROLYSE DE N-(HYDROXY-2' ETHYL) AMINO-3 PROPENOATE

The gas phas pyrolysis of various N-(2'-hydroxyethyl)-3-amino propenoates 1-6 and N-(2'-hydroxy-2'-phenyl ethyl)-3-amino propanoate 7-9 at 390 deg C-420 deg C leads respectively to formylpyrroles 11-16 and benzoylpyrroles 17-19 and, in some cases, to substituted oxazoles 36-39.The results are best explained by the intermediate formation of a dicarbonyl derivative followed either by an intramolecular thermal crotonisation or a six ? electrocyclization of an azomethine ylide.