219963-60-7Relevant articles and documents
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: Identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)
Bromidge, Steven M.,Clarke, Stephen E.,Gager, Tracey,Griffith, Kerry,Jeffrey, Phillip,Jennings, Andrew J.,Joiner, Graham F.,King, Frank D.,Lovell, Peter J.,Moss, Stephen F.,Newman, Helen,Riley, Graham,Rogers, Derek,Routledge, Carol,Serafinowska, Halina,Smith, Douglas R.
, p. 55 - 58 (2001)
Substituted N-phenyl-4-methoxy-3-piperazin-1-ylbenzenesulfonamides and conformationally restricted analogues have been identified as high affinity and selective 5-HT6 antagonists. Compounds from this series had a range of pharmacokinetic profiles in rat and in general there was a correlation between clearance and CNS penetration. Based on its overall biological profile 2 (SB-357134) was selected for further pre-clinical evaluation. (C) 2000 Elsevier Science Ltd.
Indole derivatives and its application on the medicament
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Paragraph 0222; 0232-0235, (2019/03/28)
The invention provides indole derivatives or stereisomers, tautomers, nitrogen oxides, solvate, metabolic products, pharmaceutically acceptable salts or prodrugs thereof for treating the alzheimer disease. The invention further discloses a pharmaceutical composition containing the compounds and a method of using the compounds or the pharmaceutical composition thereof to treat the alzheimer disease.
Aromatic heterocyclic derivative and its application on the medicament
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Paragraph 0202; 0208-0211, (2019/06/27)
The invention provides aromatic heterocyclic derivatives or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, which are used for treating Alzheimer's disease. The invention also disclo
