220047-75-6

Basic information

• Product Name: Trans-Tert-Butyl 2-(Hydroxymethyl)-4-Methylpyrrolidine-1-Carboxylate
• Synonyms: Trans-Tert-Butyl 2-(Hydroxymethyl)-4-Methylpyrrolidine-1-Carboxylate;(2S,4R)-1-Boc-2-hydroxymethyl-4-methylpyrrolidine;Trans-Tert-Butyl 2-(Hydroxymethyl)-4-Methylpyrrolidine-1-Carboxylate(WX641057)
• CAS NO: 220047-75-6
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.29
• Mol File: 220047-75-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Trans-Tert-Butyl 2-(Hydroxymethyl)-4-Methylpyrrolidine-1-Carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Trans-Tert-Butyl 2-(Hydroxymethyl)-4-Methylpyrrolidine-1-Carboxylate(220047-75-6)
• EPA Substance Registry System: Trans-Tert-Butyl 2-(Hydroxymethyl)-4-Methylpyrrolidine-1-Carboxylate(220047-75-6)

Safety Data

• Hazardous Substances Data: 220047-75-6(Hazardous Substances Data)

Downstream Products

• 138512-74-0 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate 
• 23009-50-9 trans-4-methyl-L-proline 
• 364750-80-1 (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid 

Relevant articles and documents

Reciprocity of steric and stereoelectronic effects in the collagen triple helix

In previous work, we demonstrated that 4-fluoroproline residues can contribute greatly to the conformational stability of the collagen triple helix, and that this stability arises from stereoelectronic effects that fix the pucker of the pyrrolidine ring and thereby preorganize the backbone properly for triple-helix formation. Here, we take a reciprocal approach, demonstrating that the steric effect of a 4-methyl group confers stability similar to that from a 4-fluoro group in the opposite configuration. Such fundamental interplay between steric and stereoelectronic effects is heretofore unknown in proteinsnatural or syntheticand provides a new means to modulate conformational stability. Copyright