220607-75-0

Basic information

• Product Name: 3,5-DIFLUOROPHENACYL BROMIDE
• Synonyms: 2-BROMO-3,5-DIFLUOROACETOPHENONE;3',5'-DIFLUOROPHENACYL BROMIDE;3,5-DIFLUOROPHENACYL BROMIDE;(R)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE, 98% MIN.;2-bromo-1-(3,5-difluorophenyl)ethanone;2-Bromo-3',5'-difluoroacetophenone, 2-Bromo-1-(3,5-difluorophenyl)ethan-1-one;Ethanone, 2-bromo-1-(3,5-difluorophenyl)-;3,5-Difluorophenacylbromide98%
• CAS NO: 220607-75-0
• Molecular Formula: C₈H₅BrF₂O
• Molecular Weight: 235.03
• Mol File: 220607-75-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 246℃
• Flash Point: 102℃
• Appearance: /
• Density: 1.649 g/cm³
• Vapor Pressure: 0.0281mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,5-DIFLUOROPHENACYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIFLUOROPHENACYL BROMIDE(220607-75-0)
• EPA Substance Registry System: 3,5-DIFLUOROPHENACYL BROMIDE(220607-75-0)

Safety Data

• Hazard Codes: C,F
• Hazardous Substances Data: 220607-75-0(Hazardous Substances Data)

Usage

Description

3,5-Difluorophenacyl bromide, with the molecular formula C9H7BrF2O, is a synthetic organic compound and a derivative of phenacyl bromide. It is a benzyl bromide derivative characterized by the presence of two fluorine atoms attached to the benzene ring, which makes it a valuable precursor for the incorporation of fluorine atoms into organic molecules. 3,5-DIFLUOROPHENACYL BROMIDE is widely utilized in organic synthesis for the formation of carbon-carbon and carbon-heteroatom bonds, particularly in the production of fine chemicals and pharmaceutical compounds. Its unique structure and reactivity have also led to its use in the development of potential anticonvulsant and analgesic agents through the synthesis of biologically active molecules.

Uses

Used in Pharmaceutical Synthesis:
3,5-Difluorophenacyl bromide is used as a reagent in pharmaceutical synthesis for the construction of carbon-carbon and carbon-heteroatom bonds. Its ability to introduce fluorine atoms into organic molecules makes it a valuable precursor in the development of various pharmaceutical compounds.
Used in Agrochemical Synthesis:
In the agrochemical industry, 3,5-Difluorophenacyl bromide is used as a reagent for the synthesis of various agrochemical compounds. Its unique structure and reactivity contribute to the development of effective and targeted agrochemical products.
Used in the Development of Anticonvulsant and Analgesic Agents:
3,5-Difluorophenacyl bromide is used as a key intermediate in the synthesis of potential anticonvulsant and analgesic agents. Its involvement in the synthesis of biologically active compounds has led to the discovery of new therapeutic options for the treatment of epilepsy and pain management.
Used in Organic Synthesis for Fine Chemicals Production:
3,5-Difluorophenacyl bromide is utilized in organic synthesis as a reagent for the production of fine chemicals. Its ability to form carbon-carbon and carbon-heteroatom bonds makes it a versatile building block in the synthesis of a wide range of specialty chemicals.

InChI:InChI=1/C8H5BrF2O/c9-4-8(12)5-1-6(10)3-7(11)2-5/h1-3H,4H2

Upstream product

• 123577-99-1 3′,5′-difluoroacetophenone 
• 67-56-1 methanol 
• 461-96-1 3,5-difluorobromobenzene 
• 186581-53-3 diazomethane 
• 455-40-3 3,5-difluorobenzoic acid 

Downstream Products

• 842140-51-6 3-(3,5-difluorophenyl)-3-oxopropanenitrile 
• 1189570-09-9 methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate 
• 1189570-10-2 (9aR)-8-allyl-7(S)-(3,5-difluorophenyl)hexahydropyrazino[2,1-c][1,4]oxazin-9(6H)-one 
• 1189570-08-8 (9aR)-8-allyl-7(R)-(3,5-difluorophenyl)hexahydropyrazino[2,1-c][1,4]oxazin-9(6H)-one 
• 1189569-40-1 (2R)-5-{(1E)-3-[(7R,9aR)-7-(3,5-difluorophenyl)-9-oxohexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3 '-pyrrolo[2,3-b]pyridin]-2'(1'H)-one 5 
• 1395931-48-2 2-(3,5-difluorophenyl)-4H-chromen-4-one 
• 1257388-52-5 ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluorophenyl)-2-hydroxyiminoethyl]amino}-(tetrahydropyran-4-yl)acetate 

Relevant articles and documents

Synthesis and photoelectric properties of IrIIIcomplexes using fluorobenzylimidazole[2,1-b]thiazole derivatives as primary ligands

3-Methyl-6-(3,5-difluorophenyl)imidazo[2,1-b]thiazole (mdfpit) and 3-methyl-6-(3,4,5-trifluorophenyl)imidazo[2,1-b]thiazole (mtfpit) were easily prepared from thiourea, acetone, and 3,5-difluorobenzoyl bromide or 3,4,5-trifluorobenzoyl bromide. These were used as primary ligands to synthesize twelve phosphorescent IrIIIcomplexes with picolinic acid (pic), isoquinoline-3-carboxylic acid (3-IQA), quinoline-2-carboxylic acid (2-QA), 2-(pyridin-2-yl)phenol (2-ylppy), 2-(2,4-difluorophenyl)pyridine (dfppy), and pyridine-2-sulfonic acid (2-sappy) as auxiliary ligands. Their structures, photoluminescence, and electrochemical properties were investigated. Upon introducing more fluorine atoms into the benzene ring of the primary ligand, the thermal stability, photoluminescence quantum yield (PLQY), LUMO energy level, and luminous efficiency of the resulting IrIIIcomplexes are significantly improved, and the photoluminescence emission spectra are blue-shifted. Their maximum emission wavelengths are present in the range of 517-618 nm, and the luminous colors span from the green to red light region. Using the synthesized IrIIIcomplexes as emitters, LED chips based on InGaN chip excitation were developed, which showed good performances. Among all LEDs, the PLQY of the (mtfpmt)2Ir(pic) based LED is 58.4%, and the luminous efficiency is as high as 17.11 lm W?1; the luminous efficiency of the (mdfpmt)2Ir(2-QA) based LED is 3.41 lm W?1with CIE coordinates of 0.60 and 0.38, which are very similar to the saturated standard red light emission. The results demonstrate the potential of the studied IrIIIcomplexes as candidates for LED materials.

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.