220905-98-6Relevant articles and documents
Concise synthesis of optically active ring-A substituted tryptophans
Ma, Chunrong,Liu, Xiaoxiang,Yu, Shu,Zhao, Shuo,Cook, James M.
, p. 657 - 660 (1999)
A concise synthesis of optically active tryptophan derivatives was developed via diastereoselective alkylation of the Schollkopf chiral auxiliary 4 to provide alkyne 2 which underwent palladium-catalyzed heteroannulation with iodoanilines 1 to furnish protected tryptophans 3. Hydrolysis and subsequent saponification of 3 provided the desired tryptophans 12 in good yields.
