22102-92-7

Basic information

• Product Name: N-hydroxysuccinimide caproic acid ester
• Synonyms: N-hydroxysuccinimide caproic acid ester;N-(Hexanoyloxy)succinimide;1-[(1-Oxohexyl)oxy]-2,5-pyrrolidinedione;Hexanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester
• CAS NO: 22102-92-7
• Molecular Formula: C₁₀H₁₅NO₄
• Molecular Weight: 213.23
• Product Categories: Heterocycles;Miscellaneous Reagents
• Mol File: 22102-92-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 52-54°C
• Boiling Point: 302.1°Cat760mmHg
• Flash Point: 136.5°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.00101mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: N-hydroxysuccinimide caproic acid ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxysuccinimide caproic acid ester(22102-92-7)
• EPA Substance Registry System: N-hydroxysuccinimide caproic acid ester(22102-92-7)

Safety Data

• Hazardous Substances Data: 22102-92-7(Hazardous Substances Data)

Usage

Chemical Properties

N-hydroxysuccinimide caproic acid ester is White Solid

Uses

Different sources of media describe the Uses of 22102-92-7 differently. You can refer to the following data:
1. Reagent used to prepare biosynthetic polymer surfactants designed for shear-stable endothelialization.
2. N-hydroxysuccinimide caproic acid ester is used to prepare biosynthetic polymer surfactants designed for shear-stable endothelialization.

InChI:InChI=1/C10H15NO4/c1-2-3-4-5-10(14)15-11-8(12)6-7-9(11)13/h2-7H2,1H3

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 142-62-1 hexanoic acid 

Downstream Products

• 1080673-12-6 C₂₀H₃₂O₃Si 
• 1039560-15-0 C₂₀H₃₂O₃Si 
• 1354638-35-9 N-[4-(1,3-dioxacyclopent-2-yl)benzyl]hexanamide 
• 1354638-38-2 N-(4-formylbenzyl)hexanamide 
• 1354638-46-2 C₁₈H₂₇N₂O₅ 
• 1354638-41-7 α-(4-hexanamidomethyl)phenyl-N-(2-hydroxymethyl-1,3-dihydroxy-2-propyl)nitrone 
• 1072896-47-9 p-methoxyphenyl (3,5,9-trideoxy-5-glycolamido-9-hexanamido-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-β-D-galactopyranoside 
• 428510-08-1 Hexanoic acid ((3S,4R)-4-hydroxy-2-oxo-tetrahydro-furan-3-yl)-amide 
• 123725-50-8 N-<(2RS,2'S)-2-<2-(hexanoylamino)-5-hydroxypentyloxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester 

Relevant articles and documents

Formation of 1-hydroxymethylene-1,1-bisphosphinates through the addition of a silylated phosphonite on various trivalent derivatives

An easily handled one-pot synthetic procedure was previously developed for the synthesis of bisphosphinates starting from acyl chlorides. Herein, other trivalent derivatives as acid anhydrides and activated esters were tested to form various bisphosphinates. This modulation of the reactivity can be controlled according to the nature of the acid derivative for the use of sensitive and functionalized substrates.

MODIFIED CYTIDINE NUCLEOTIDES AND THEIR USE

The present invention describes W-position modified cytidine nucleotides of formula (I). Provided herein are methods of chemical synthesis of ΛΡ-modified cytidine nucleoside triphosphates and their applications as well as uses of the cytidine analogues for the synthesis of modified nucleic acids. The nucleic acid molecule comprises DNA, RNA or a combination of DNA/RNA. One of many applications of modified cytidine nucleotides described herein is enzyme selection, when an enzyme of interest bears an activity of an esterase, amidase, oxidoreductase, lyase, ligase or other enzymatic activity, formula (I) wherein the substituants are as defined in the appended claims.

Synthesis and Characterization of Fatty Acid Grafted Chitosan Polymer and Their Nanomicelles for Nonviral Gene Delivery Applications

The aim of this study was to synthesize and characterize fatty acid-grafted-chitosan (fatty acid-g-CS) polymer and their nanomicelles for use as carriers for gene delivery. CS was hydrophobically modified using saturated fatty acids of increasing fatty acyl chain length. Carbodiimide along with N-hydroxysuccinimide was used for coupling carboxyl group of fatty acids with amine groups of CS. Proton nuclear magnetic resonance and Fourier transform infrared spectroscopy were used to quantify fatty acyl substitution onto CS backbone. The molecular weight distribution of the synthesized polymers was determined using size exclusion high performance liquid chromatography and was found to be in range of the parent CS polymer (～50 kDa). The critical micelle concentration (cmc) of the polymers was determined using pyrene as a fluorescent probe. The cmc was found to decrease with an increase in fatty acyl chain length. The amphiphilic fatty acid-g-CS polymers self-assembled in an aqueous environment to form nanomicelles of ～200 nm particle size and slightly positive net charge due to the cationic nature of free primary amino groups on CS molecule. These polymeric nanomicelles exhibited excellent hemo- and cytocompatibility, as evaluated by in vitro hemolysis and MTT cell viability assay, respectively, and showed superior transfection efficiency compared to unmodified chitosan and naked DNA. The surface of these nanomicelles can be further modified with ligands allowing for selective targeting, enhanced cell binding, and internalization. These nanomicelles can thus be exploited as potential nonviral gene delivery vectors for safe and efficient gene therapy.