221044-26-4

Basic information

• Product Name: 2-Oxazolidinone, 3-[(3R)-1-oxo-3-phenylpentyl]-4-phenyl-, (4S)-
• CAS NO: 221044-26-4
• Molecular Formula: C20H21NO3
• Molecular Weight: 323.392
• Mol File: 221044-26-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-[(3R)-1-oxo-3-phenylpentyl]-4-phenyl-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-[(3R)-1-oxo-3-phenylpentyl]-4-phenyl-, (4S)-(221044-26-4)
• EPA Substance Registry System: 2-Oxazolidinone, 3-[(3R)-1-oxo-3-phenylpentyl]-4-phenyl-, (4S)-(221044-26-4)

Safety Data

• Hazardous Substances Data: 221044-26-4(Hazardous Substances Data)

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 174485-45-1 (4S)-3-((2E)-pent-2-enoyl)-4-phenyl oxazolidin-2-one 
• 100-59-4 phenylmagnesium chloride 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 5669-17-0 (R) 3-phenylvaleric acid 
• 876755-15-6 (S)-3-((2S,3S)-2-azido-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 2880-06-0 (R)-(+)-methyl 3-phenylpentanoate 
• 159563-71-0 3-([S]-α-ethylbenzyl)-4-hydroxy-6-([R]-α-ethylphenethyl)-2H-pyran-2-one 

Relevant articles and documents

Diastereoselective copper-catalysed 1,4-addition of Grignard reagents to N-enoyl oxazolidinones

Conjugate additions of organometallic reagents to α,β- unsaturated carboxylic acid derivatives give access to numerous β-substituted chiral building blocks. Chiral oxazolidinones serve as useful surrogates of carboxylic function in the asymmetric conjugate addition of Grignard reagents. N-Enoyl oxazolidinones undergo this 1,4-addition with a catalytic amount of copper salt and using either chiral or achiral phosphine ligands. In particular, chiral ferrocenyl phosphane oxazolines proved useful in achieving high diastereoselectivities. The resulting N-acyl oxazolidinones were obtained in good yields and with high diastereoselectivities (up to single diastereomer).

A facile asymmetric synthesis of 1,2,3-substituted indenes

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