221079-70-5

Basic information

• Product Name: ethyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-hydroxypropionate
• Synonyms: ethyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-hydroxypropionate
• CAS NO: 221079-70-5
• Molecular Weight: 324.492
• Mol File: 221079-70-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-hydroxypropionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-hydroxypropionate(221079-70-5)
• EPA Substance Registry System: ethyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-hydroxypropionate(221079-70-5)

Safety Data

• Hazardous Substances Data: 221079-70-5(Hazardous Substances Data)

Upstream product

• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 141-78-6 ethyl acetate 

Downstream Products

• 1202576-66-6 ethyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-ethoxypropionate 
• 1202575-81-2 3-ethoxy-3-{4-[(4-fluoronaphthalen-1-yl)methoxy]phenyl}propanoic acid 
• 1610979-30-0 3-ethoxy-3-{4-[(4-methylbenzyl)oxy]phenyl}propanoic acid 
• 1610979-29-7 3-ethoxy-3-{4-[(3-methylbenzyl)oxy]phenyl}propanoic acid 

Relevant articles and documents

Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558

GPR40 agonists stimulate insulin secretion only under the presence of high glucose concentration. Based on this mechanism, GPR40 agonists are believed to be promising novel insulin secretagogues with low risk of hypoglycemia. The optimizations of 3-aryl-3-ethoxypropanoic acids were performed to improve in vitro activity. We discovered compound 29r (DS-1558), (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propanoic acid, which was confirmed to have an enhancing effect on glucose-dependent insulin secretion after intravenous glucose injection in SD rats.