221318-25-8

Basic information

• Product Name: 2-<(2-acetoxymethylphenyl)thiomethyl>-1H-pyrrole
• Synonyms: 2-<(2-acetoxymethylphenyl)thiomethyl>-1H-pyrrole
• CAS NO: 221318-25-8
• Molecular Weight: 261.345
• Mol File: 221318-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-<(2-acetoxymethylphenyl)thiomethyl>-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(2-acetoxymethylphenyl)thiomethyl>-1H-pyrrole(221318-25-8)
• EPA Substance Registry System: 2-<(2-acetoxymethylphenyl)thiomethyl>-1H-pyrrole(221318-25-8)

Safety Data

• Hazardous Substances Data: 221318-25-8(Hazardous Substances Data)

Upstream product

• 4892-02-8 Methyl thiosalicylate 
• 221318-23-6 2-<(2-methoxycarbonylphenyl)thiomethyl>-1H-pyrrole 
• 4521-31-7 o-hydroxymethyl thiophenol 
• 27472-36-2 2-hydroxymethylpyrrole 
• 108-24-7 acetic anhydride 
• 221318-24-7 2-<(2-hydroxymethylphenyl)thiomethyl>-1H-pyrrole 
• 221318-26-9 thiosalicyl acetate 

Downstream Products

• 221318-28-1 2-<(2-hydroxymethylphenyl)thiomethyl>-5-trichloroacetyl-1H-pyrrole 
• 221318-29-2 2-<(2-hydroxymethylphenyl)thiomethyl>-5-trifluoroacetyl-1H-pyrrole 
• 221318-27-0 2-<(2-hydroxymethylphenyl)thiomethyl>-1H-pyrrole-2-carboxyaldehyde 

Relevant articles and documents

Polycondensed heterocycles. X. A new method for the preparation of pyrrolo[2,1-c][1,4]benzothiazepines by intramolecular Mitsunobu cyclisation

A modified Mitsunobu reaction of 2-hydroxymethylpyrrole and suitable thiophenol derivatives lead to intermediates which can be easily elaborated and eventually cyclised to the title compounds. The cyclisation step consists of another Mitsunobu reaction variation by which an 'activated' pyrrole is N- alkylated intramolecularly, under very mild conditions.