221324-51-2Relevant articles and documents
Gold-catalyzed asymmetric allylic substitution of free alcohols: An enantioselective approach to chiral chromans with quaternary stereocenters for the synthesis of Vitamin E and analogues
Uria, Uxue,Vila, Carlos,Lin, Ming-Yuan,Rueping, Magnus
supporting information, p. 13913 - 13917 (2016/02/18)
The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitamin E family) and analogues has been accomplished employing a new enantioselective gold catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps. The methodology proved to be applicable to different olefins highlighting its potential for the synthesis of diverse libraries. The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitamin E family) and analogues has been accomplished employing an enantioselective gold-catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps (see scheme).
Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents
Hellberg, Mark R.,Namil, Abdelmoula,Delgado, Pete,David, Karen C.,Kessler, Timothy L.,Graff, Gustav,Haggard, Karen S.,Nixon, Jon C.
, p. 267 - 276 (2007/10/03)
A series of phenolic antioxidant ester and amide derivatives of the nonsteroidal antiinflammatory drug naproxen was designed to have both antiinflammatory and cytoprotective activity. Compounds were evaluated in vitro both for antioxidant activity, as ass
