221915-84-0

Basic information

• Product Name: 3-(2-DIMETHYLAMINOETHOXY)-BROMOBENZENE
• Synonyms: 3-(2-DIMETHYLAMINOETHOXY)-BROMOBENZENE;[2-(3-BROMO-PHENOXY)-ETHYL]-DIMETHYL-AMINE;UKRORGSYN-BB BBV-070799;2-(3-BroMophenoxy)-N,N-diMethylethanaMine
• CAS NO: 221915-84-0
• Molecular Formula: C₁₀H₁₄BrNO
• Molecular Weight: 244.13
• Mol File: 221915-84-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 280 °C at 760 mmHg
• Flash Point: 123.1 °C
• Appearance: /
• Density: 1.309 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2-DIMETHYLAMINOETHOXY)-BROMOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-DIMETHYLAMINOETHOXY)-BROMOBENZENE(221915-84-0)
• EPA Substance Registry System: 3-(2-DIMETHYLAMINOETHOXY)-BROMOBENZENE(221915-84-0)

Safety Data

• Hazardous Substances Data: 221915-84-0(Hazardous Substances Data)

Usage

General Description

3-(2-Dimethylaminoethoxy)-bromobenzene is a chemical compound that consists of a bromobenzene ring with a dimethylaminoethoxy group attached to it. 3-(2-Dimethylaminoethoxy)-bromobenzene has the formula C10H14BrNO and a molecular weight of 250.12 g/mol. It is commonly used in organic chemistry research and can act as a reagent in various chemical reactions. The dimethylaminoethoxy group increases the compound's solubility in polar solvents, making it useful in solution-based experiments. This chemical may also have applications in the production of pharmaceuticals and agrochemicals due to its unique structure and reactivity.

Upstream product

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 108-36-1 1,3-dibromobenzene 
• 591-20-8 3-Bromophenol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 107-99-3 2-(dimethylamino)ethyl chloride 

Downstream Products

• 925940-40-5 dimethyl-{2-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-ethyl}-amine 
• 1139717-84-2 3-(2-(dimethylamino)ethoxy)phenylboronic acid 
• 1186607-01-1 N-(3-(3-(2-(dimethylamino)ethoxy)phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide 
• 1350815-99-4 9-chloro-2-({3-[2-(dimethylamino)ethoxy]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 221915-82-8 [4-[2-(N,N-dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone 
• 221915-86-2 [3-[2-(N,N-Dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone 
• 1171042-36-6 cyclopropyl-{5-[3-(2-dimethylamino-ethoxy)-phenyl]-[2,2';4',3]terpyridin-6'-yl}-amine 

Relevant articles and documents

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of polo-like kinase 1 (MLN0905)

This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pharmacodynamic experiments demonstrated prolonged mitotic arrest after oral administration of 12c to tumor bearing nude mice. A subsequent efficacy study in nude mice achieved tumor growth inhibition or regression in a human colon tumor (HT29) xenograft model.

ORGANIC COMPOUNDS

Compounds of formula (I) in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Trifluoromethyl ketone analogs as selective cPLA2 inhibitors

Selective inhibitors of the cPLA2enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where (R′), p, D, Y, Z, Ra, Rband A are as defined in the specification.