222550-60-9

Basic information

• Product Name: (S)-N-ethylalanine Methyl ester
• Synonyms: (S)-N-ethylalanine Methyl ester;N-Ethyl-L-valine methyl ester;(S)-Methyl 2-(ethylaMino)-3-Methylbutanoate;L-Valine, N-ethyl-, methyl ester
• CAS NO: 222550-60-9
• Molecular Formula: C8H17NO2
• Molecular Weight: 159.22608
• Mol File: 222550-60-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 190.7±23.0 °C(Predicted)
• Appearance: /
• Density: 0.917g/ml
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.78±0.19(Predicted)
• CAS DataBase Reference: (S)-N-ethylalanine Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-ethylalanine Methyl ester(222550-60-9)
• EPA Substance Registry System: (S)-N-ethylalanine Methyl ester(222550-60-9)

Safety Data

• Hazardous Substances Data: 222550-60-9(Hazardous Substances Data)

Usage

General Description

(S)-N-Ethylalanine methyl ester is a chemical compound that is derived from the amino acid ethylalanine. It is commonly used in the synthesis of various pharmaceuticals and is also used as a chiral auxiliary in asymmetric synthesis. (S)-N-Ethylalanine methyl ester has potential application in the development of new drugs and as a building block in organic synthesis. However, it is important to handle this compound with caution as it may pose hazards to human health and the environment. Overall, (S)-N-Ethylalanine methyl ester has a versatile range of potential uses in the field of chemistry and pharmacology.

Upstream product

• 1243654-86-5 N-ethyl-N-nosyl-L-valine methyl ester 

Relevant articles and documents

N-(4-nitrophenylsulfonyl)- And N-(fluorenylmethoxycarbonyl)-N-ethyl amino acid methyl esters - A practical approach

An efficient one-pot preparation of N-ethyl-N-4-nitrophenylsulfonyl (nosyl) amino acid methyl esters was accomplished by a simple N-ethylation reaction by using triethyloxonium tetrafluoroborate in the presence of N,N- diisopropylethylamine, The N-ethylated amino acid methyl esters are obtained with total retention of stereochemistry at the original chiral centers. To further broaden the scope of this methodology, the N-ethylated nosyl-protected compounds are easily converted in the more practical fluorenylmethyloxycarbonyl (Fmoc)-protected derivatives. The cleavage of methyl ester by using a mild and neutral method enables the preparation of N-ethyl amino acids that are building blocks suitable for introduction into a peptide chain. The methodology works well with both nosyl- and Fmoc-based solution-phase peptide synthesis.