22259-53-6Relevant articles and documents
An alternative approach to the synthesis of anticancer molecule spirobrassinin and its 2′-amino analogues
Budovská, Mariana,Tischlerová, Viera,Moj?i?, Ján,Kozlov, Oleksandr,Gondová, Ta?ána
, p. 63 - 77 (2020)
Abstract: A convenient synthesis of the cruciferous phytoalexin (S)-(?)-spirobrassinin and its (±)-2′-amino analogues have been achieved. Our synthetic route towards (S)-(?)-spirobrassinin is based on the CrO3-mediated cyclization of chiral 1-(2′,3′,4′,6′-tetra-O-acetyl-?-D-glucopyranosyl)brassinin and subsequent removal of the chiral auxiliary. (±)-2′-Amino analogues of spirobrassinin and 1-methoxyspirobrassinin were obtained from thioureas in one step in an efficient manner with the aid of CrO3. New synthesized compounds were screened in vitro for antiproliferative/cytotoxic activity against six human cancer cell lines by MTT assay. Amino analogues with CF3 functionality displayed good antiproliferative effect. Graphic abstract: [Figure not available: see fulltext.].
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Gower,Leete
, p. 3683 (1963)
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SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE
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Page/Page column 256, (2017/08/01)
The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof, or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof, and methods and compositions for treating or ameliorating abnormal cell proliferative disorders, such as cancer, wherein A, R2, R3, R10, E1, E2, E3, Y, and Z are as defined herein.
