2229-36-9Relevant articles and documents
Amide compound containing 1-phenyl-1,2,3-triazole structure and application thereof
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Paragraph 0095; 0096; 0097; 0098, (2018/12/13)
The invention discloses an amide compound containing 1-phenyl-1,2,3-triazole and application thereof. The amide compound containing 1-phenyl-1,2,3-triazole is characterized by having a formula shown in the attached figure, wherein R1 is selected from the
Organocatalytic triazole formation, followed by oxidative aromatization: Regioselective metal-free synthesis of benzotriazoles
Ramachary, Dhevalapally B.,Shashank, Adluri B.
supporting information, p. 13175 - 13181 (2013/10/01)
Herein we report on our studies on the sequential one-pot combinations of amine-catalyzed multicomponent reactions (MCRs). We have developed the copper-free synthesis of functionalized bicyclic N-aryl-1,2,3-triazole and N-arylbenzotriazole products 4 and 5 from the simple unmodified starting materials through [3+2]-cycloaddition ([3+2]-CA) and oxidative aromatization reactions in one pot under amine catalysis. The sequential one-pot reaction proceeds in good yields with high selectivity by using pyrrolidine as the catalyst from the simple unmodified substrates of enones, aryl azides, and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Furthermore, we have demonstrated the medicinal applications of products 4 and 5 through simple organic reactions. Organo-click approach to benzotriazoles: A practical synthesis of N-arylbenzotriazoles was achieved through the sequential one-pot combination of [3+2]-cycloaddition followed by 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (DDQ)-mediated oxidative aromatization of unmodified cyclic enones with aryl azides. For the first time, the synthesis of privileged CF3 containing N-arylbenzotriazoles through metal-free catalysis has been discovered (see scheme). Copyright
