22296-13-5Relevant articles and documents
Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin
Sun, Haiyang,Li, Hui,Wang, Jiayi,Song, Gonghua
, p. 977 - 980 (2018)
Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita (M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 μmol/L.