22298-04-0

Basic information

• Product Name: 2-fluoro-6,11-dihydrothiochromeno[4,3-b]indole
• Synonyms: 6,11-dihydro-2-fluoro(1)benzothiopyrano(4,3-b)indole
• CAS NO: 22298-04-0
• Molecular Formula: C₁₅H₁₀FNS
• Molecular Weight: 255.31
• Mol File: 22298-04-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 486.4°C at 760 mmHg
• Flash Point: 247.9°C
• Density: 1.401g/cm³
• Vapor Pressure: 3.86E-09mmHg at 25°C
• Refractive Index: 1.749
• CAS DataBase Reference: 2-fluoro-6,11-dihydrothiochromeno[4,3-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-6,11-dihydrothiochromeno[4,3-b]indole(22298-04-0)
• EPA Substance Registry System: 2-fluoro-6,11-dihydrothiochromeno[4,3-b]indole(22298-04-0)

Safety Data

• Hazardous Substances Data: 22298-04-0(Hazardous Substances Data)

Upstream product

• 21243-18-5 6-fluoro-3,4-dihydro-2H-1-benzothiopyran-4-one 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 52831-39-7 Fluor-2(I)benzothiopyrano<4,3-b>indol 

Relevant articles and documents

Synthesis, characterization and antifungal evaluation of novel thiochromanone derivatives containing indole skeleton

Invasive fungal disease constitutes a growing health problem and development of novel antifungal drugs with high potency and selectivity against new fungal molecular targets are urgently needed. In order to develop potent antifungal agents, a novel series of 6-alkyl-indolo[3,2-c]-2H-thiochroman derivatives were synthesized. Microdilution broth method was used to investigate antifungal activity of these compounds. Most of them showed good antifungal activity in vitro. Compound 4o showed the best antifungal activity, which (inhibition of Candida albicans and Cryptococcus neoformans) can be achieved at the concentration of 4 μg/mL. Compounds 4b (inhibition of Cryptococcus neoformans), 4j (inhibition of Cryptococcus neoformans), 4d (inhibition of Candida albicans) and 4h (inhibition of Candida albicans) also showed the best antifungal activity at the concentrations of 4 μg/mL. The molecular interactions between 4o and the N-myristoyltransferase of Candida albicans (PDB ID: 1IYL) were finally investigated through molecular docking. The results indicated that these thiochromanone derivatives containing indole skeleton could serve as promising leads for further optimization as novel antifungal agents.