223784-25-6Relevant articles and documents
Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors
-
, (2008/06/13)
Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R1and R2are as defined in the specification) or their salts, or prodrugs or active metabolites of such compounds or salts, are useful for treating disorders and diseases such as cancer: In preferred embodiments, R1and R2are independently unsubstituted or substituted carbocyclic or heterocyclic aryl ring structures. Compounds where R2is ortho-substituted aryl are especially potent inhibitors of CDKs such as CDK4.
