22446-12-4

Basic information

• Product Name: 4-METHOXYPHENOXYACETONITRILE
• Synonyms: 2-(4-METHOXYPHENOXY)ACETONITRILE;4-METHOXYPHENOXYACETONITRILE;BUTTPARK 94\57-35;(p-Methoxyphenoxy)acetonitrile
• CAS NO: 22446-12-4
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• EINECS: -0
• Product Categories: Aromatic Nitriles;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 22446-12-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 106-110°C 0,1mm
• Flash Point: 106-110°C/0.1mm
• Appearance: /
• Density: 1.107
• Vapor Pressure: 0.00169mmHg at 25°C
• Refractive Index: 1.5270
• BRN: 2444937
• CAS DataBase Reference: 4-METHOXYPHENOXYACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYPHENOXYACETONITRILE(22446-12-4)
• EPA Substance Registry System: 4-METHOXYPHENOXYACETONITRILE(22446-12-4)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 22446-12-4(Hazardous Substances Data)

Usage

Uses

It finds it application in the synthesis of α-aryloxy-2,4-dihydroxyacetophenone 4-O-β-D-glucopyranosides and their conversion into 3-aryloxy-7-glucosyloxychromones.

InChI:InChI=1/C9H9NO2/c1-11-8-2-4-9(5-3-8)12-7-6-10/h2-5H,7H2,1H3

Upstream product

• 150-76-5 4-methoxy-phenol 
• 75-05-8 acetonitrile 
• 5720-07-0 4-methoxyphenylboronic acid 
• 590-17-0 cyanomethyl bromide 
• 624-75-9 iodoacetonitrile 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 121361-55-5 2,4-dihydroxy-α-(4-methoxyphenoxy)acetophenone 
• 243657-65-0 2-(4-methoxyphenoxy)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 261362-97-4 Isonicotinic acid [1-amino-2-(4-methoxy-phenoxy)-eth-(E)-ylidene]-hydrazide 
• 35370-92-4 2-(4-methoxy-phenoxy)-thioacetamide 
• 302952-79-0 7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one 
• 1372186-78-1 tert-butyl (2RS)-2-(3,4-dichlorophenyl)-2-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate 
• 1372186-77-0 tert-butyl [(2RS)-2-(3,4-dichlorophenyl)-2-hydroxy-3-(4-methoxyphenoxy)propyl](3-hydroxypropyl)carbamate 
• 1372186-76-9 (2RS)-2-(3,4-dichlorophenyl)-2-[(4-methoxyphenoxy)methyl]oxirane 
• 1372186-75-8 1,2-dichloro-4-{1-[(4-methoxyphenoxy)methyl]ethenyl}benzene 
• 1372186-69-0 tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate 
• 1372186-68-9 4-benzyl-7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane 
• 1372186-67-8 4-benzyl-7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepan-3-one 
• 1372186-66-7 4-(benzylamino)-2-(3,4-dichlorophenyl)-1-(4-methoxyphenoxy)butan-2-ol 
• 1372186-65-6 N-benzyl-2-chloro-N-[3-(3,4-dichlorophenyl)-3-hydroxy-4-(4-methoxyphenoxy)butyl]acetamide 

Relevant articles and documents

Synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile

A new and efficient protocol for the synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile has been developed using eco-friendly hydrogen peroxide as oxidant under metal-free conditions. This method is compatible with arylboronic acid attached sensitive substituent and obtains desired product in moderate to good yield.

SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS

Described herein are certain steroid derivative compounds, for example of formula (I): wherein X1, X2, X3 L, and Ar are as defined herein, pharmaceutical compositions comprising such compounds, the use of such compounds and compositions to specifically target glucocorticoid action, and the use of such compounds and compositions in the treatment of acute and chronic inflammatory conditions, in particular rheumatoid arthritis, haematological and other malignancies, and for causing immunosuppression in the prevention or treatment of transplant rejection, as well as methods of preparing such compounds.

CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER

4-Chromenone derivatives of the formula I herein that inhibit the ubiquitin-mediated degradation of p27, are useful for the treatment of cancer.