225232-58-6

Basic information

• Product Name: 6-benzyl-2,4-dimethoxy-5-isopropylpyrimidine
• Synonyms: 6-benzyl-2,4-dimethoxy-5-isopropylpyrimidine
• CAS NO: 225232-58-6
• Molecular Weight: 272.347
• Mol File: 225232-58-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-benzyl-2,4-dimethoxy-5-isopropylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-2,4-dimethoxy-5-isopropylpyrimidine(225232-58-6)
• EPA Substance Registry System: 6-benzyl-2,4-dimethoxy-5-isopropylpyrimidine(225232-58-6)

Safety Data

• Hazardous Substances Data: 225232-58-6(Hazardous Substances Data)

Upstream product

• 225232-14-4 6-benzyl-2,4-dichloro-5-isopropylpyrimidine 
• 6921-34-2 benzylmagnesium chloride 
• 909546-83-4 2-(4-bromo-2,6-dimethoxypyrimidin-5-yl)propan-2-ol 
• 909546-84-5 4-bromo-5-isopropyl-2,6-dimethoxypyrimidine 
• 100-39-0 benzyl bromide 
• 1780-42-3 2,4,6-trichloro-5-isopropylpyrimidine 
• 67-56-1 methanol 

Downstream Products

• 176519-55-4 6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione 
• 149950-60-7 Emivirine 

Relevant articles and documents

Chemo- and regioselective functionalization of uracil derivatives. Applications to the synthesis of oxypurinol and emivirine

A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo- and regioselective bromine/magnesium exchange reaction on 5-bromo-4-halogeno-2,6-dimethoxypyrimidines has been developed. Applications to the synthesis of pharmaceuticals such as oxypurinol and emivirine are reported.

Regioselective alkylation and arylation at the 6-position of pyrimidine: Synthesis of 5-alkyl-6-arylmethyl-2,4-pyrimidinediones

5-Alkyl-2,4,6-trichloropyrimidines reacted with various nucleophiles to afford the regioselectivity 6-substituted pyrimidines as the major products in good yields, which were transformed to 5-alkyl-6-arylmethyl-2,4- pyrimidinediones of a key intermediate