22536-62-5

Basic information

• Product Name: 2-CHLORO-5-PHENYL-PYRIMIDINE
• Synonyms: 2-CHLORO-5-PHENYL-PYRIMIDINE;2-Chloro-5-phenyl-pyridimine;PyriMidine,2-chloro-5-phenyl-
• CAS NO: 22536-62-5
• Molecular Formula: C₁₀H₇ClN₂
• Molecular Weight: 190.63
• EINECS: 200-589-5
• Product Categories: pharmacetical;pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 22536-62-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 131-133 °C
• Boiling Point: 369.9 °C at 760 mmHg
• Flash Point: 209.1 °C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 2.45E-05mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.71±0.22(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-PHENYL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-PHENYL-PYRIMIDINE(22536-62-5)
• EPA Substance Registry System: 2-CHLORO-5-PHENYL-PYRIMIDINE(22536-62-5)

Safety Data

• Hazardous Substances Data: 22536-62-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-phenylpyrimidine is a chemical compound with the molecular formula C10H7ClN2. It is a pyrimidine derivative with a chlorine atom attached to the second carbon and a phenyl group attached to the fifth carbon of the pyrimidine ring. 2-CHLORO-5-PHENYL-PYRIMIDINE is used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It has been studied for its potential anti-cancer and anti-inflammatory properties, and it is also used in the synthesis of various heterocyclic compounds. 2-Chloro-5-phenylpyrimidine is a versatile and important chemical with a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H7ClN2/c11-10-12-6-9(7-13-10)8-4-2-1-3-5-8/h1-7H

Upstream product

• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 98-80-6 phenylboronic acid 
• 100-59-4 phenylmagnesium chloride 
• 71-43-2 benzene 
• 3958-47-2 triphenylindium 
• 56863-46-8 1-methyl-5-phenyl-2(1H)-pyrimidinone 
• 33266-29-4 1-isopropyl-5-phenyl-1H-pyrimidin-2-one 
• 33266-26-1 1-ethyl-5-phenyl-1H-pyrimidin-2-one 
• 960-16-7 tributylphenylstannane 
• 27956-19-0 1-methyl-5-phenylpyrimidin-2(1H)-one 

Downstream Products

• 76972-24-2 methyl-(5-phenyl-2-pyrimidinyl)propanedioic acid diethyl ester 
• 75175-43-8 2-hydrazino-5-phenylpyrimidine 
• 350581-71-4 4-(5-phenyl-pyrimidin-2-yl)-morpholine 
• 1048338-59-5 isopropyl-(5-phenyl-pyrimidin-2-yl)-amine 
• 101987-05-7 phenyl-(5-phenyl-pyrimidin-2-yl)-amine 
• 31408-23-8 5-phenyl-pyrimidin-2-ylamine 

Relevant articles and documents

ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME

The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent device having a low driving voltage and/or a high luminous efficiency and/or a long lifes

Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors

Based on perlolyrine (1), a natural alkaloid with weak PDE5 potency from the traditional Chinese aphrodisiac plant Tribulus terrestris L., a series α-substituted tetrahydro-β-carboline (THβC) derivatives were synthesized via T+BF4--mediated oxidative C–H functionalization of N-aryl THβCs with diverse potassium trifluoroborates. Following Winterfeldt oxidation afforded the corresponding furyl/thienyl pyrroloquinolones, of which 5-ethylthiophene/ethylfuran derivatives 20a–b were identified as the most potent and selective PDE5 inhibitors. Among the enantiomers, (S)-20a and (S)-20b (IC50 = 0.52 and 0.39 nM) were found to be more effective than their (R)-antipode, display favorable pharmacokinetic profiles, exert in vitro vasorelaxant effects on the isolated thoracic aorta, and exhibit in vivo efficacy in the anesthetized rabbit erectile model.

NOVEL SUBSTITUTED PYRIMIDINE COMPOUNDS

The invention relates to novel substituted pyrimidine compounds of general formula (I), in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.