22610-18-0

Basic information

• Product Name: 2-Phenylazetidine
• Synonyms: 2-Phenylazetidine;2-phenylazetidine(SALTDATA: FREE);2-Phenylazetidine HCl
• CAS NO: 22610-18-0
• Molecular Formula: C₉H₁₁N
• Molecular Weight: 133.19034
• EINECS: 200-589-5
• Mol File: 22610-18-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 216 °C at 760 mmHg
• Flash Point: 85.2 °C
• Appearance: /
• Density: 1.015 g/cm³
• Vapor Pressure: 0.143mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• PKA: 10.44±0.40(Predicted)
• CAS DataBase Reference: 2-Phenylazetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenylazetidine(22610-18-0)
• EPA Substance Registry System: 2-Phenylazetidine(22610-18-0)

Safety Data

• Hazardous Substances Data: 22610-18-0(Hazardous Substances Data)

Usage

General Description

2-Phenylazetidine is a chemical compound with the molecular formula C10H13N. It is a white to light yellow solid with a molecular weight of 147.22 g/mol. 2-Phenylazetidine belongs to the class of azetidines, which are four-membered heterocycles containing one nitrogen atom. 2-Phenylazetidine is used in organic synthesis as a building block for the preparation of various pharmaceuticals and agricultural chemicals. It is known to exhibit biological activity, and its derivatives have been studied for their potential applications in drug discovery and development. Additionally, 2-Phenylazetidine has been investigated for its potential use as a ligand in metal-organic frameworks and as a chiral building block in asymmetric synthesis.

InChI:InChI=1/C9H11N/c1-2-4-8(5-3-1)9-6-7-10-9/h1-5,9-10H,6-7H2

Upstream product

• 100-42-5 styrene 
• 5661-55-2 4-phenylazetidin-2-one 

Downstream Products

• 4360-51-4 cinnamylamine 
• 560080-39-9 2-(4-chlorophenyl)-N-(3,3-diphenylpropyl)acetamide 
• 1312573-21-9 2-(4-chlorophenyl)-1-(2-phenylazetidin-1-yl)ethanone 
• 1542817-55-9 N-(tert-butoxycarbonyl)-2-phenylazetidine 
• 1542817-58-2 1-tert-butyl-2-(methyldiphenylsilyl)-2-phenylazetidine-1-carboxylate 
• 1609694-26-9 5-chloro-3-((2-phenylazetidin-1-yl)methyl)benzo[d]oxazol-2(3H)-one 

Relevant articles and documents

Easy access to constrained peptidomimetics and 2,2-disubstituted azetidines by the unexpected reactivity profile of α-lithiated N-Boc-azetidines

The reactivity profile of lithiated N-Boc-2-arylazetidines has been investigated filling a gap in the chemistry of this class of four-membered heterocycles. Two unexpected and unprecedented results have been observed: an "ortho-effect" accounting for the regioselective functionalization of the azetidine ring, and self-condensation leading to new and interesting azetidine-based peptidomimetics.

6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM

The present invention relates to compounds defined by formula (I), wherein the groups X, Y, W and R 1 to R 4 are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are agonists of the 5-HT2C receptor, and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this receptor, such as metabolic and CNS-related disorders

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.