226387-12-8

Basic information

• Product Name: C₁₆H₁₈N₂O
• CAS NO: 226387-12-8
• Molecular Weight: 254.332
• Mol File: 226387-12-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 399.4±15.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)
• CAS DataBase Reference: C₁₆H₁₈N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈N₂O(226387-12-8)
• EPA Substance Registry System: C₁₆H₁₈N₂O(226387-12-8)

Safety Data

• Hazardous Substances Data: 226387-12-8(Hazardous Substances Data)

Upstream product

• 5470-96-2 quinoline 2-carbaldehyde 
• 3907-02-6 2‐amino‐3,3‐dimethylbutan‐1‐ol 
• 1436-43-7 quinoline-2-carbonitrile 
• 112245-13-3 (S)-tert-leucinol 

Relevant articles and documents

Catalytic Cyclooligomerization of Enones with Three Methylene Equivalents

Cyclic structures are highly represented in organic molecules, motivating a wealth of catalytic methods targeting their synthesis. Among the various ring-forming processes, cyclooligomerization reactions possess several attractive features but require addressing a unique challenge associated with controlling ring-size selectivity. Here we describe the catalytic reductive cocyclooligomerization of an enone and three carbene equivalents to generate a cyclopentane, a process that constitutes a formal [2 + 1 + 1 + 1]-cycloaddition. The reaction is promoted by a (quinox)Ni catalyst and uses CH2Cl2/Zn as the C1 component. Mechanistic studies are consistent with a metallacycle-based pathway, featuring sequential migratory insertions of multiple carbene equivalents to yield cycloalkanes larger than cyclopropanes.

Pd(II)/tBu-quinolineoxazoline: An Air-Stable and modular chiral catalyst system for enantioselective oxidative cascade cyclization

[Chemical Equation Presented] An air-stable and structurally tunable chiral tBu-quinolineoxazoline/Pd(II) catalyst system has been developed for the enantioselective oxidative cascade cyclization of a variety of disubstituted olefinic substrates, with the apparent advantages of good yields and excellent enantioselectivities (up to 98% ee) and diastereoselectivities (dr >24:1). A transition-state model has also been proposed to account for the excellent stereocontrol.

Steric effects of the ligand in the enantioselective palladium-catalyzed allylic alkylation using chiral oxazolinylpyridines

Eight new chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium-catalyzed allylic substitution of 1,3- diphenylprop-2-enyl acetate with dimethyl malonate. Catalytic activity and enantioselectivity were found to be highly