22686-82-4

Basic information

• Product Name: 2,3-diphenylquinazolin-4(3H)-one
• Synonyms: 2,3-Diphenyl-4(3H)-quinazolinone; 2,3-Diphenylquinazolin-4(3H)-one; 4(3H)-Quinazolinone, 2,3-diphenyl-; Quinazolin-4(3H)-one, 2,3-diphenyl-
• CAS NO: 22686-82-4
• Molecular Formula: C₂₀H₁₄N₂O
• Molecular Weight: 298.338
• Mol File: 22686-82-4.mol
• Article Data: 63

Chemical Properties

• Boiling Point: 477.1°C at 760 mmHg
• Flash Point: 242.4°C
• Density: 1.17g/cm³
• Vapor Pressure: 2.87E-09mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 2,3-diphenylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenylquinazolin-4(3H)-one(22686-82-4)
• EPA Substance Registry System: 2,3-diphenylquinazolin-4(3H)-one(22686-82-4)

Safety Data

• Hazardous Substances Data: 22686-82-4(Hazardous Substances Data)

Usage

General Description

2,3-diphenylquinazolin-4(3H)-one is a chemical compound with the molecular formula C20H14N2O. It is a quinazolinone derivative, and its structure consists of a quinazoline ring system with two phenyl groups attached at positions 2 and 3. 2,3-diphenylquinazolin-4(3H)-one has been studied for its potential pharmacological activities, including antimicrobial, antifungal, and anti-inflammatory properties. It has also been investigated for its potential as a scaffold for the development of new drugs. Additionally, 2,3-diphenylquinazolin-4(3H)-one has been evaluated for its potential as an antioxidant and its ability to inhibit certain enzymes. Its diverse biological activities make it an interesting target for further research and potential therapeutic applications.

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Relevant articles and documents

Metal-free catalyst for the visible-light-induced photocatalytic synthesis of quinazolinones

In the present work, we have developed a novel and environmentally friendly method for the synthesis of quinazolinones using fluorescein as a photocatalyst via a condensation reaction of o-aminobenzamides and aldehydes under visible light irradiation. In this protocol, neither toxic oxidants nor transition-metal catalysts were needed, and a series of quinazolinones could be obtained in high efficiencies. In addition, this reaction can be extended to gram levels and has a large potential of wide application in future industrialization.

Complementary Reactivity in Selective Radical Processes: Electrochemistry of Oxadiazolines to Quinazolinones

Electrochemistry has recently emerged as a sustainable approach for efficiently generating radical intermediates utilizing eco-friendly electric energy. An electrochemical process was developed to transform 1,2,4-oxadiazolines under mild conditions. The electrochemical N-O bond cleavage at a controlled oxidation potential led to the selective synthesis of quinazolinone derivatives that could not be obtained by photocatalytic radical processes, indicating complementary reactivities in radical processes. The electrochemical reaction pathways were fully revealed by density functional theory-based investigations.

Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp3 carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95percent. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles. This journal is