226907-95-5

Basic information

• Product Name: 6-Amino-9-benzyl-2-(isopropylamino)purine
• Synonyms: 6-Amino-9-benzyl-2-(isopropylamino)purine
• CAS NO: 226907-95-5
• Molecular Weight: 282.348
• Mol File: 226907-95-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Amino-9-benzyl-2-(isopropylamino)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-9-benzyl-2-(isopropylamino)purine(226907-95-5)
• EPA Substance Registry System: 6-Amino-9-benzyl-2-(isopropylamino)purine(226907-95-5)

Safety Data

• Hazardous Substances Data: 226907-95-5(Hazardous Substances Data)

Upstream product

• 5451-40-1 2,6 dichloropurine 

Downstream Products

• 226908-10-7 6-Amino-9-benzyl-8-bromo-2-(isopropylamino)purine 

Relevant articles and documents

Synthesis and structure-activity relationships of 2-amino-8- hydroxyadenines as orally active interferon inducing agents

Recently, we have reported the 8-hydroxyadenine derivatives (2-4) as a novel class of interferon (IFN) inducing agents. In the present study, a series of 8-hydroxyadenines, which possess various amino moieties at the adenine C(2)-position, were synthesized and evaluated for their ability to induce endogenous IFN in comparison to the known active agent, Imiquimod. Among the compounds prepared, compound 9o possessing a 2-methoxyethylamino group at C(2)-position of adenine was found to exhibit potent IFN inducing activity in vivo. Compound 9o induced IFN from the dosage of 0.1 mg/kg, which was 30-fold potent than that of Imiquimod, and showed a good oral bioavailability (F=81%).