227288-15-5

Basic information

• Product Name: tert-butyl [3-(2-aminophenyl)prop-2-yn-1-yl]carbamate
• Synonyms: tert-butyl [3-(2-aminophenyl)prop-2-yn-1-yl]carbamate
• CAS NO: 227288-15-5
• Molecular Weight: 246.309
• Mol File: 227288-15-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl [3-(2-aminophenyl)prop-2-yn-1-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [3-(2-aminophenyl)prop-2-yn-1-yl]carbamate(227288-15-5)
• EPA Substance Registry System: tert-butyl [3-(2-aminophenyl)prop-2-yn-1-yl]carbamate(227288-15-5)

Safety Data

• Hazardous Substances Data: 227288-15-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 615-43-0 2-iodophenylamine 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 

Downstream Products

• 103549-24-2 tert-butyl [2-(1H-indol-3-yl)ethyl]carbamate 
• 227288-28-0 (R)-2-[2-(3-{(R)-2-[2-(3-tert-Butoxycarbonylamino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid 
• 227288-25-7 (R)-2-[2-(3-{(R)-2-[2-(3-tert-Butoxycarbonylamino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid methyl ester 
• 744185-23-7 (R)-2-[2-(3-{(R)-2-[2-(3-Amino-prop-1-ynyl)-phenylamino]-propionylamino}-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid 
• 227288-23-5 2-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenylamino]-propionic acid 
• 227288-19-9 2-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenylamino]-propionic acid methyl ester 
• 227288-21-3 2-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenylamino]-4-methyl-pentanoic acid methyl ester 
• 114622-04-7 ascididemin 

Relevant articles and documents

Total synthesis of ascididemin-type alkaloids using alkyne building blocks

A common approach to ascididemin-type alkaloids, including ascididemin, bromoleptoclinidinone, neocalliactine acetate, and 11-hydroxyascididemin, based on a Bronsted acid-promoted tandem annulation has been developed. Alkyne building blocks were first des

Hydroformylation of 2-Alkynylanilines: Toward an Alternative Methodology for the Synthesis of 3-Substituted Indoles

A potentially viable route for the synthesis of 3-substituted indoles is presented herein. The methodology is based on a regioselective Rh-catalysed hydroformylation of prepared 2-alkyn-1-ylanilines. The requisite 2-alkynylaniline substrates were prepared in high yields (>85 %) using the Pd-catalysed Sonogashira reaction. A catalyst complex that comprises RhI(CO)(PPh3)3 and 1,2-bis(diphenylphosphino)ethane as the ligand allowed the quantitative conversions of the alkynyl substrates with selectivities >75 % for the desired 3-substituted indoles.