227471-20-7

Basic information

• Product Name: Mucrolidin
• Synonyms: Mucrolidin;(+)-1beta,4beta,6alpha-Trihydroxyeudesmane
• CAS NO: 227471-20-7
• Molecular Formula: C15H28O3
• Molecular Weight: 256.38102
• Mol File: 227471-20-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Mucrolidin(CAS DataBase Reference)
• NIST Chemistry Reference: Mucrolidin(227471-20-7)
• EPA Substance Registry System: Mucrolidin(227471-20-7)

Safety Data

• Hazardous Substances Data: 227471-20-7(Hazardous Substances Data)

Usage

General Description

Mucrolidin is a mixture of organic chemicals with antiviral, antibacterial, and anti-inflammatory properties. It is primarily composed of mucoproteins and polysaccharides, which help strengthen the body's immune system and protect against infections. Mucrolidin has been shown to have significant therapeutic effects on respiratory conditions such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD), by reducing inflammation and promoting the clearance of mucus from the lungs. Additionally, it has been found to exhibit antiviral activity against influenza and other respiratory viruses, making it a potential treatment for viral respiratory infections. Overall, Mucrolidin is a promising natural remedy for respiratory illnesses, with potential benefits for immune health and respiratory function.

Upstream product

• 95457-12-8 6β-acetoxy-1β,4β-dihydroxyeudesmane 
• 95457-12-8 1β,4β-dihydroxy-6β-acetoxy-eudesmane 
• 95457-15-1 1β,4β,6β-trihydroxyeudesmane 
• 148795-97-5 4β,6β-dihydroxyeudesman-1-one 

Relevant articles and documents

Improved microbiological hydroxylation of sesquiterpenoids: semisynthesis, structural determination and biotransformation studies of cyclic sulfite eudesmane derivatives.

Two new cyclic sulfite eudesmane derivatives have been investigated. Their (R) and (S) sulfur configuration and the structural arrangement of their "A" rings have been assigned by means of their 13C and 1H NMR chemical shifts and have been confirmed by single-crystal X-ray analyses. Microbial-transformation of these epimer cyclic sulfites and their dihydroxyeudesmane precursor have been studied using the hydroxylating fungus Rhizopus nigricans. Increased biocatalysis rates and considerable differences in the biotransformation of both cyclic sulfite eudesmanes have been found. Promising 8alpha,11-dihydroxy derivatives have been isolated from the (S)-diastereomer bioconversion.

Senedensiscins A-F: Six new eudesmane sesquiterpenoid glucosides from Senecio densiserratus

Six new highly oxygenated eudesmane sesquiterpenoid glucosides, senedensiscins A-F (1-6), were isolated from the aerial parts of Senecio densiserratus. Their structures with the absolute configurations were established on the basis of spectroscopic analyses and chemical methods. These compounds represent an unprecedented type of sesquiterpenoid glucoside with the angeloyl group directly connected to the glucosyl moiety and their cytotoxicity was evaluated against the selected human cell lines, HL-60, SMMC-7721, and HeLa.

TERPENOIDS FROM SIDERITIS VAROI SUBSP. ORIENSIS

Key Word Index - Sideritis varoi subsp. oriensis; Labiatae; eudesmanes. From the aerial parts of Sideritis varoi subsp. oriensis the previously known 1β-hydroxy-6β-acetoxyeudesm-4(15)-ene, 1β-hydroxy-6B-acetoxyeudesm-3-ene, 1β-hydroxy-6β-acetoxyeudesm-4-ene, 1β,4β-dihydroxy-6β-acetoxyeudesmane and the new 1β,4α-dihydroxy-6β-acetoxyeudesmane, as wel as the ent-8α-hydroxylabda-13(16),14-dienes 6-deoxyandalusoic acid, 6-deoxyandalusal, 6-deoxyandalusol, 18-deoxyandalusol, andalusol, the ent-13-epi-manoyl oxide varodiol and the ent-kaur-15-ene sideridiol were isolated.The stereochemistry at C-4 of the isolated eudesmanes, which has been under discussion for other similar compounds, was elucidated by chemical and spectroscopic means.

Chemical-Microbiological Synthesis of 6β-Eudesmanolides from 11-Hydroxyl Derivatives obtained by Rhizopus nigricans cultures: Synthesis of 6β-Dendroserins.

The relationship between the structure of the substrates and the action of the fungus Rhizopus nigricans has been studied in order to obtain, in the highest possible yield, 11-hydroxyl derivatives which were dehydrates to the "exo" position, hydroborated with 9-BBN and oxidized with RuH2(PPh3)4 to give 11-R and 11-S-6-epi-dendroserin.In course of the biotransformation processes, 8α-hydroxyl and 7α-hydroxyl derivatives were also obtained, as well as the oxidation of the hydroxyl groups at C-1, an unusual process with Rhizopus nigricans.We have proved that the eudesmanones are more easily hydroxylated at C-11 than the hydroxyeudesmane compounds.Key Words: Biotransformation; 6β-eudesmanolides; 11-hydroxyeudesmanes; Rhizopus nigricans