22780-52-5

Basic information

• Product Name: 3-AMino-1H-isoindole
• Synonyms: 3-AMino-1H-isoindole;1H-Isoindol-3-aMine;1H-Isoindole, 3-amino-
• CAS NO: 22780-52-5
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• Mol File: 22780-52-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 3-AMino-1H-isoindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMino-1H-isoindole(22780-52-5)
• EPA Substance Registry System: 3-AMino-1H-isoindole(22780-52-5)

Safety Data

• Hazardous Substances Data: 22780-52-5(Hazardous Substances Data)

Usage

General Description

3-Amino-1H-isoindole is a heterocyclic compound with the molecular formula C9H8N2. It is a light yellowish to brown colored solid that is sparingly soluble in water. 3-AMino-1H-isoindole is used in organic synthesis and pharmaceutical research as a building block for various chemical reactions. It is also used as an intermediate in the production of dyes, pigments, and pharmaceuticals. Its chemical structure and properties make it useful in the development of new materials and compounds for industrial and scientific applications.

Upstream product

• 40508-03-0 2-(azidomethyl)benzonitrile 
• 81675-06-1 5-methoxy-1H-2,4-benzodiazepine 
• 95605-79-1 5,5-dimethoxy-4,5-dihydro-1H-2,4-benzodiazepine 
• 20377-03-1 4-azidoisoquinoline 
• 1207507-57-0 1-amino-3H-isoindole hydrobromide 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 157117-83-4 2-<(2-Cyan-phenyl)methyl>-2H-isoindol-1,3-dion 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 1180486-10-5 2-(1-imino-1,3-dihydroisoindol-2-yl)-1-(3-pentafluorosulfanylphenyl)ethanone hydrobromide 
• 97934-39-9 1-[11H,13H-Benzo[5,6][1,3]diazepino[2,1-a]isoindol-(6E)-ylidene]-3-phenyl-thiourea 
• 97934-38-8 1-[11H,13H-Benzo[5,6][1,3]diazepino[2,1-a]isoindol-(6E)-ylidene]-3-phenyl-urea 
• 61001-00-1 2-phenyl-5H-imidazo<2,1-a>isoindole 
• 61001-46-5 2-phenyl-5H-imidazo<2,1-a>isoindole hydrochloride 
• 87773-20-4 N-phenacyl phthalimidine 
• 97934-35-5 hydrochloride of 2-(o-cyanobenzyl)-1-imino-3H-isoindole 

Relevant articles and documents

Imidazole derivatives as PDE10A enzyme inhibitors

This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr

The Curtin-Hammett principle in action: 1-amino-3H-isoindole in cycloaddition reactions

Based on the spectral studies of 1-aminoisoindole we have observed that in solution the isoindolenine tautomer predominates. In spite of this fact but, taking into account the Curtin-Hammett principle, we undertaken the first study of the Diels-Alder reaction for 1-aminoisoindole as a typical representative of simple isoindoles in isoindoline form. We have studied the interaction of 1-aminoisoindole with maleimide derivates and demonstrated that the products are rearranged 1:2 composition adducts. We have proposed a rearrangement mechanism, detected and identified the intermediate Diels-Alder products containing both endo- and exo adducts.

Cyclizations of N-Stannylaminyl Radicals onto Nitriles

(Matrix presented) Stannylaminyl radicals derived from radical reactions of Bu3SnH with azidoalkylmalononitriles exhibit highly efficient 5- and 6-exo cyclization onto either nitrile group to give aminoiminyl radicals that in turn are reduced t