22795-99-9Relevant articles and documents
A (S)- l - ethyl -2 - aminomethylpentazane industrial manufacturing method (by machine translation)
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Paragraph 0073-0074; 0077, (2017/04/03)
The present invention provides a (S)- l - ethyl -2 - aminomethylpentazane industrial manufacturing method, characterized in that in order to 4 - hydroxy butyraldehyde as the substrate, under the action of in ethylamine generated by the reaction ring ortho-substituted 1 - ethyl pyrrolidine, after the reduction reaction to obtain the target product. In the present invention uses a novel, high-yield (S)- l - ethyl -2 - aminomethylpentazane method, the method is different from the traditional synthetic method, without complicated purification process, can be one-pot synthesis to realize, the process route avoids complex of problems and purification problems by-product. (by machine translation)
Highly diastereoselective synthesis of chiral aminophenolate zinc complexes and isoselective polymerization of rac-lactide
Wang, Haobing,Ma, Haiyan
, p. 8686 - 8688 (2013/09/23)
An enantiopure zinc complex supported by an aminophenolate ligand with multiple stereogenic centers has been diastereoselectively synthesized via the variation of the ortho-substituent of a phenoxy moiety and the N-alkyl group of a chiral pyrrolidinyl ring in the ligand framework, which displays high isoselectivity in the polymerization of rac-lactide.
Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: High-affinity ligands for CNS dopamine D2 receptors
Bishop,Mathis,Gerdes,Whitney,Eaton,Mailman
, p. 1612 - 1624 (2007/10/02)
A number of 2,3-dimethoxy-5-(fluoroalkyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl] benzamides (with or without a 6-hydroxy group) were synthesized and evaluated as dopamine D2 receptor ligands. The parent acids were synthesized via the Claisen rearrangement of the appropriate O-allyl ethers, which were derived from o-vanillic acid or 2,3-dimethoxysalicylic acid. A decrease in reactivity was found to be characteristic of pentasubstituted benzoates, and difficulties were encountered with the introduction of fluorine onto the ethyl side chains. The (fluoroethyl)- and (fluoropropyl)salicylamides were 5 times more potent than the corresponding benzamides in inhibiting [3H]spiperone binding to the D2 receptor. These (fluoroalkyl)salicylamides are of potential value for in vivo positron emission tomography (PET) studies upon the basis of their relatively selective, high potency binding affinity for the D2 receptor.