228857-58-7

Basic information

• Product Name: 1,2-Azetidinedicarboxylicacid, 1-(1,1-dimethylethyl) ester, (2R)-
• Synonyms: (R)-N-tert-Butoxycarbonylazetidine-2-carboxylicacid
• CAS NO: 228857-58-7
• Molecular Formula: C₉H₁₅NO₄
• Molecular Weight: 201.2197
• Mol File: 228857-58-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 320.999 °C at 760 mmHg
• Flash Point: 147.935 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 6.35E-05mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: 2-8°C
• PKA: 4.01±0.20(Predicted)
• CAS DataBase Reference: 1,2-Azetidinedicarboxylicacid, 1-(1,1-dimethylethyl) ester, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Azetidinedicarboxylicacid, 1-(1,1-dimethylethyl) ester, (2R)-(228857-58-7)
• EPA Substance Registry System: 1,2-Azetidinedicarboxylicacid, 1-(1,1-dimethylethyl) ester, (2R)-(228857-58-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 228857-58-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C9H15NO4/c1-9(2,3)14-8(13)10-5-4-6(10)7(11)12/h6H,4-5H2,1-3H3,(H,11,12)/t6-/m1/s1

Upstream product

• 174740-80-8 (R)-1-tosylazetidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7732-18-5 water 
• 2517-04-6 Azetidine-2-carboxylic acid 
• 7729-30-8 (R)-azetidine-2-carboxylic acid 

Downstream Products

• 1005756-63-7 (R)-tert-butyl 2-(azidomethyl)azetidine-1-carboxylate 
• 887626-82-6 (R)-tert-butyl 2-(aminomethyl)azetidine-1-carboxylate 
• 161511-90-6 (R)-1-t-butyloxycarbonyl-2-azetidinemethanol 
• 935668-80-7 (R)-azetidin-2-ylmethanol hydrochloride 

Relevant articles and documents

CHEMICAL COMPOUNDS AS H-PGDS INHIBITORS

A compound of formula (I) wherein R1, R2, R3, R4, X, Y, and A are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

3-Pyridyl enantiomers and their use as analgesics

The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: STR1 or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.