22889-29-8

Basic information

• Product Name: 1-(4-methoxybenzylidene)-2-(4-fluorophenyl)hydrazine
• Synonyms: 1-(4-methoxybenzylidene)-2-(4-fluorophenyl)hydrazine
• CAS NO: 22889-29-8
• Molecular Weight: 244.268
• Mol File: 22889-29-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxybenzylidene)-2-(4-fluorophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxybenzylidene)-2-(4-fluorophenyl)hydrazine(22889-29-8)
• EPA Substance Registry System: 1-(4-methoxybenzylidene)-2-(4-fluorophenyl)hydrazine(22889-29-8)

Safety Data

• Hazardous Substances Data: 22889-29-8(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 371-14-2 4-fluorophenylhydrazine 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 1207462-44-9 C₁₉H₁₆FN₅O₅ 

Relevant articles and documents

Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones

Fluorinated aryl- and heteroaryl-substituted monohydrazones displayed excellent broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis of murine red blood cells than that of VRC at the same concentrations, possessed fungicidal activity in a time-kill study, and exhibited no mammalian cell cytotoxicity. In addition, these monohydrazones prevented the formation of biofilms that otherwise block antibiotic effectiveness and did not trigger the development of resistance when exposed to C. auris AR Bank # 0390 over 15 passages.

Synthesis, crystal structure, optical and electrochemical properties of novel diphenylether-based formazan derivatives

In this study, formazans 5a-5h were synthesized by coupling the reactions of substituted phenylhydrazone compounds 3a-3h with diazonium salt of 4-chloro-2-phenoxybenzenamine (4). The substituted phenylhydrazones 3a-3h were obtained from the condensation o

Parallel synthesis of pyrazolines on soluble polymer support

An efficient and rapid parallel liquid-phase synthesis of pyrazolines has been developed. The one-pot three-components reaction of polyethylene glycol (PEG)-supported acrylate 1, aldehyde 2 and aryl hydrazine 3 in the presence of chloramine-T in methanol gave the corresponding PEG-supported pyrazolines 5. Cleavage from the support under mild conditions afforded pyrazolines 6 in good yields (69-91%) and high purities (91-100%).