22900-83-0

Basic information

• Product Name: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLATE;ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOX&;Ethyl 2-bromop4-methyl-1,3-thiazole-5-carboxylate;2-bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester;Ethyl 2-broMo-4-Methylthiazole-5-carboxylate;Ethyl 2-broMo-4-Methylthiazole-5-carboxylate 97%;2-Bromo-4-methyl-5-thiazolecarboxylic acid ethyl ester
• CAS NO: 22900-83-0
• Molecular Formula: C₇H₈BrNO₂S
• Molecular Weight: 250.11
• Product Categories: Thiazole series;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiazoles;ThiazolesHeterocyclic Building Blocks;thiazole, carboxylate
• Mol File: 22900-83-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 65-69 °C(lit.)
• Boiling Point: 287.086 °C at 760 mmHg
• Flash Point: 127.426 °C
• Appearance: /
• Density: 1.573 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.10±0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(22900-83-0)
• EPA Substance Registry System: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(22900-83-0)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36
• RIDADR: 1759
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 22900-83-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

It finds its application in the preparation of thiazole-4- and -5-carboxylates, and an infrared study of their rotational isomers and in the discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.

InChI:InChI=1/C7H8BrNO2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3

Upstream product

• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 110-46-3 isopentyl nitrite 
• 84911-18-2 ethyl 2-bromoacetoacetate 
• 141-97-9 ethyl acetoacetate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 78633-83-7 2-(p-Acetylaminobenzenesulfonamido)-4-methyl-5-carboethoxythiazole 
• 40003-41-6 2-bromo-4-methyl-thiazole-5-carboxylic acid 
• 40003-13-2 2-(4-chloro-3-methyl-phenoxy)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 53040-04-3 2-(4-methoxycarbonylmethoxy-phenylsulfanyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58535-97-0 2-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58535-99-2 2-[4-(2-methoxycarbonyl-ethoxy)-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58535-98-1 2-[4-(1-methoxycarbonyl-ethoxy)-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58536-01-9 2-[4-(3-methoxycarbonyl-propoxy)-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-24-5 4-methyl-2-(toluene-4-sulfonyl)-thiazole-5-carboxylic acid ethyl ester 
• 40003-26-7 2-(4-chloro-benzenesulfonyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-23-4 2-benzenesulfonyl-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-25-6 2-(4-acetylamino-benzenesulfonyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58536-00-8 2-[4-(2-methoxycarbonyl-ethoxy)-3-methyl-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-15-4 ethyl 4-methyl-2-phenylsulfanylthiazole-5-carboxylate 

Relevant articles and documents

Green synthesis approaches of 2-bromo-4-methyl thiazole-5-carboxamide derivatives as potent microbial agents

As a part of our ongoing research in the development of new, selective and environmental friendly methodologies, herein we report a new series of 2-bromo-4-methylthiazole-5-carboxamide derivatives using polyethylene glycol-400 (PEG-400) as a solvent. All

Facile synthesis of novel (1-Aryl/alkyl-1H-1,2,3-triazol- 4-yl)methyl-2-bromo-4-methylthiazole-5-carboxylates by Cu(I) catalyzed click reaction

A number of novel thiazole-triazole heterocycles bearing (1-aryl/alkyl-1H-1,2,3-triazol-4-yl)methyl- 2-bromo-4-methylthiazole-5-carboxylates was synthesized through the click reaction. The structure of all new synthesized compounds was established by sup

NOVEL OXAZOLE AND THIAZOLE COMPOUNDS AS Β-CATENIN MODULATORS AND USES THEREOF

Heterocyclic compounds according to formula I: wherein A, B, Y, and Cy are as described herein, are provided as inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of B-cat. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and other conditions related to Wnt pathway dysfunction, including various cancers and pulmonary fibrosis.