2292-16-2 Usage
Description
Neferine is a bisbenzylisoquinoline alkaloid derived from Nelumbo nucifera, characterized by its unique chemical structure featuring four methoxyl groups, one hydroxyl, and two methylimino groups. It has been extensively studied through chemical degradation and spectroscopic data analysis.
Uses
Used in Anticancer Applications:
Neferine is used as an antitumor agent for enhancing the therapeutic effects of Mitomycin-C in hela cells. It is particularly effective in the treatment of cervical cancers, where it activates the p38-MAPK pathway, leading to improved outcomes in cancer treatment.
Used in Pharmaceutical Industry:
Neferine is used as a promising pharmaceutical candidate due to its ability to interact with biopolymers and macromolecules, making it a versatile compound for various applications within the industry.
Biochem/physiol Actions
Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
References
Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)
Check Digit Verification of cas no
The CAS Registry Mumber 2292-16-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,9 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2292-16:
(6*2)+(5*2)+(4*9)+(3*2)+(2*1)+(1*6)=72
72 % 10 = 2
So 2292-16-2 is a valid CAS Registry Number.
InChI:InChI=1/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1
2292-16-2Relevant articles and documents
Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera
Nishimura, Katsumi,Horii, Shinji,Tanahashi, Takao,Sugimoto, Yumi,Yamada, Jun
, p. 59 - 68 (2013/02/23)
Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.