23012-19-3

Basic information

• Product Name: 1-(4-Methyloxazol-5-yl)ethanone
• Synonyms: 1-(4-METHYLOXAZOL-5-YL)ETHANONE;5-Acetyl-4-methyloxazole;1-(4-Methyl-1,3-oxazol-5-yl)ethan-1-one;Ketone, Methyl 4-Methyl-5-oxazolyl
• CAS NO: 23012-19-3
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.13
• Mol File: 23012-19-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 15-15.5 °C(Solv: methanol (67-56-1))
• Boiling Point: 190.592 °C at 760 mmHg
• Flash Point: 69.068 °C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0.537mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: 2-8°C
• PKA: -1.14±0.14(Predicted)
• CAS DataBase Reference: 1-(4-Methyloxazol-5-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methyloxazol-5-yl)ethanone(23012-19-3)
• EPA Substance Registry System: 1-(4-Methyloxazol-5-yl)ethanone(23012-19-3)

Safety Data

• Hazardous Substances Data: 23012-19-3(Hazardous Substances Data)

Usage

General Description

1-(4-Methyloxazol-5-yl)ethanone is a chemical compound with the molecular formula C7H9NO2. It is a ketone derivative with a 4-methyl oxazole ring attached to the ethanone group. 1-(4-Methyloxazol-5-yl)ethanone is used in the field of organic chemistry as a building block for the synthesis of various other compounds. It can also be used as a fragrance ingredient, contributing to the aroma of certain perfumes and flavors. Additionally, it has potential applications in pharmaceuticals and agrochemicals due to its unique chemical structure and properties. Overall, 1-(4-Methyloxazol-5-yl)ethanone has diverse potential uses in different industries and research fields.

InChI:InChI=1/C6H7NO2/c1-4-6(5(2)8)9-3-7-4/h3H,1-2H3

Upstream product

• 77287-34-4 formamide 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 70345-38-9 5-hydroxy-4,6-dimethylpyridimine 
• 161531-34-6 5-(2-benzyloxy-1,1-dmethoxy)ethyl-4-methyloxazole 
• 161531-36-8 4-benzyloxymethyl-5-hydroxy-6-methylpyrimidine 
• 161531-35-7 5-(2-benzyloxyacetyl)-4-methyloxazole 
• 101708-13-8 5-hydroxy-4-hydroxymethyl-6-methylpyrimidine 

Relevant articles and documents

6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation

A novel series of aminotrimethylpyridinol and aminodimethylpyrimidinol derivatives were designed and synthesised for FGFR4 inhibitors. Structure-activity relationship on the FGFR4 inhibitory activity of the new compounds was clearly elucidated by an intensive molecular docking study. Anti-cancer activity of the compounds was evaluated using hepatocellular carcinoma (HCC) cell lines and a chick chorioallantoic membrane (CAM) tumour model. Compound 6O showed FGFR4 inhibitory activity over FGFR1 ? 3. Compared to the positive control BLU9931, compound 6O exhibited at least 8 times higher FGFR4 selectivity. Strong anti-proliferative activity of compound 6O was observed against Hep3B, an HCC cell line which was a much more sensitive cell line to BLU9931. In vivo anti-tumour activity of compound 6O against Hep3B-xenografted CAM tumour model was almost similar to BLU9931. Overall, compound 6O, a novel derivative of aminodimethylpyrimidinol, was a selective FGFR4 kinase inhibitor blocking HCC tumour growth.