23019-61-6

Basic information

• Product Name: 1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide
• Synonyms: 1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide
• CAS NO: 23019-61-6
• Molecular Formula: Br*C₁₅H₁₆NO₂
• Molecular Weight: 322.19704
• Product Categories: Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 23019-61-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: Methanol, Water
• CAS DataBase Reference: 1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide(23019-61-6)
• EPA Substance Registry System: 1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide(23019-61-6)

Safety Data

• Hazardous Substances Data: 23019-61-6(Hazardous Substances Data)

Usage

Description

1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide is an organic compound that serves as an intermediate in the preparation of Iso Guvacine (I819560), a GABAA receptor agonist. It is a white solid with specific chemical properties that make it suitable for use in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide is used as an intermediate in the synthesis of Iso Guvacine (I819560), which is a GABAA receptor agonist. Its role in the production of this agonist is crucial for the development of potential treatments for various conditions related to the GABAA receptor, such as anxiety, insomnia, and epilepsy.
As an intermediate, 1-Benzyl-4-carboxy-pyridiniuM Ethyl Ester BroMide plays a significant role in the chemical synthesis process, contributing to the development of new pharmaceutical compounds with potential therapeutic applications.

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 100-39-0 benzyl bromide 

Downstream Products

• 24228-40-8 N-benzyl isonipecotic acid ethyl ester 
• 23019-62-7 ethyl 1-benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate 
• 76036-35-6 N-benzyl-4-carbethoxypyridinyl 
• 184900-16-1 1,4-dibenzyl-piperidine-4-carboxylic acid ethyl ester 

Relevant articles and documents

Metal-free reduction of unsaturated carbonyls, quinones, and pyridinium salts with tetrahydroxydiboron/water

A series of unsaturated carbonyls, quinones, and pyridinium salts have been effectively reduced to the corresponding saturated carbonyls, dihydroxybenzenes, and hydropyridines in moderate to high yields with tetrahydroxydiboron/water as a mild, convenient, and metal-free reduction system. Deuterium-labeling experiments have revealed this protocol to be an exclusive transfer hydrogenation process from water. This journal is

Reactions of N-benzyl-pyridinium or -isoquinolinium ylides with ethyl 3-fluoro-3-(fluoroalkyl)acrylates to give fluoroalkyl-substituted indolizine and pyrrolo[2,1-a]isoquinoline derivatives

In the presence of base, N-benzylpyridinium and N-benzylisoquinolinium ylides generated in situ from the N-benzyl-pyridinium or -isoquinolinium bromides react with ethyl 3-fluoro-3-fluoroalkyl(except bromodifluoromethyl)acrylates to give one or two fluoro

Photochemistry of Stable Pyridinyl Radicals. Photolysis of N-Alkyl-4-(carboalkoxy)pyridinyls

Photoinduced decomposition of N-benzyl-4-carbethoxypyridinyl (1a), N-methyl- (1b) and N-benzyl-4-(carbomethoxy)pyridinyl (1c), and their mixture was studied in degassed acetonitrile.N-benzyl homologues (1a and 1c) were smoothly photolyzed to ethyl (or methyl) isonicotinate by loss of a benzyl group, whereas the N-methyl homologue (1b) was comparatively stable toward UV light; the rate of disappearance of 1c relative to that of 1b was 11:1.A mechanism is postulated, which involves the formation of an alkyl radical by C-N bond homolysis followed by attack on the pyridinyl radical to form dihydropyridines.This is supported by a plot of the yield of ethyl isonicotinate vs. the ratio of initial concentrations 0/0.Pyridinyl radicals 1 possess their absorption maxima at around 300, 395, and 630 nm; those at 300 and 395 nm maxima participate in this reaction.