2303-25-5

Basic information

• Product Name: 1-(3-Methylphenoxy)-4-nitrobenzene
• Synonyms: 1-Methyl-3-(4-nitrophenyl)oxybenzene;Attackweed;HE-314;RH-8378;TOPE;1-Methyl-3-(4-nitrophenoxy)benzene;1-(3-Methylphenoxy)-4-nitrobenzene
• CAS NO: 2303-25-5
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.2313
• Mol File: 2303-25-5.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 334.7°Cat760mmHg
• Flash Point: 142.2°C
• Appearance: /
• Density: 1.218g/cm³
• Vapor Pressure: 0.000245mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 1-(3-Methylphenoxy)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Methylphenoxy)-4-nitrobenzene(2303-25-5)
• EPA Substance Registry System: 1-(3-Methylphenoxy)-4-nitrobenzene(2303-25-5)

Safety Data

• Hazardous Substances Data: 2303-25-5(Hazardous Substances Data)

Usage

General Description

1-(3-Methylphenoxy)-4-nitrobenzene is a chemical compound with the molecular formula C13H11NO3. It is a nitroaromatic compound containing a nitro group (-NO2) and a phenoxy group (-OC6H4CH3) attached to a benzene ring. 1-(3-Methylphenoxy)-4-nitrobenzene is commonly used in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It has also been studied for its potential use as a precursor in the production of dyes and pigments. The compound has been investigated for its pharmacological properties, including its potential as an anti-inflammatory and analgesic agent. Additionally, it is important to handle this compound with care, as it is considered to be hazardous and harmful if ingested or inhaled.

InChI:InChI=1/C13H11NO3/c1-10-3-2-4-13(9-10)17-12-7-5-11(6-8-12)14(15)16/h2-9H,1H3

Upstream product

• 108-39-4 3-methyl-phenol 
• 100-00-5 4-chlorobenzonitrile 
• 636-98-6 p-nitrobenzene iodide 
• 1077-02-7 3-methylphenyl methanesulfonate 
• 350-46-9 4-Fluoronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 17933-03-8 m-tolylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 100-25-4 para-dinitrobenzene 

Downstream Products

• 59003-95-1 2-nitro-5-(4-nitro-phenoxy)-benzoic acid 
• 873977-84-5 acetic acid-[4-(4-bromo-3-methyl-phenoxy)-2-nitro-anilide] 
• 873977-67-4 acetic acid-[4-(4-chloro-3-methyl-phenoxy)-2-nitro-anilide] 
• 860597-21-3 2-bromo-5-(4-nitro-phenoxy)-benzoic acid 
• 873980-25-7 4-(4-bromo-3-methyl-phenoxy)-2-nitro-aniline 
• 873980-51-9 4-(4-chloro-3-methyl-phenoxy)-2-nitro-aniline 
• 873977-88-9 acetic acid-[4-(4-bromo-3-methyl-phenoxy)-anilide] 
• 873977-71-0 acetic acid-[4-(4-chloro-3-methyl-phenoxy)-anilide] 
• 192768-36-8 {(R)-1-[(4-m-Tolyloxy-phenylamino)-methyl]-2-tritylsulfanyl-ethyl}-carbamic acid tert-butyl ester 
• 22532-72-5 3-Methyl-4-chlor-4'-nitrodiphenylaether 
• 246511-70-6 1-bromo-2-methyl-4-(4-nitrophenoxy)benzene 
• 147837-21-6 3-(4-nitrophenoxy)benzyl bromide 
• 135210-04-7 (3-methyl-4-nitro-phenyl)-(4-nitro-phenyl)-ether 
• 27237-21-4 3-(4-nitrophenoxy)benzoic acid 

Relevant articles and documents

Preparation and characterization of Cu based on 5,5'-bistetrazole as a recyclable metal-organic framework and application in synthesis of diaryl ether by the Ullmann coupling reaction

Cu based on 5,5′-bistetrazole ([Cu2BT · 2H2O] n) as a recyclable metal-organic framework (MOF) heterogeneous catalyst was characterized by FT-IR, 13C NMR, XRD, SEM, EDX, BET, BJH, and ICP-AES analysis. The catalytic activity of the catalyst was probed through the Ullmann reaction for synthesis of diaryl ether derivatives from two component reactions of aromatic arylhalides and phenol derivatives in DMSO. Simple procedure, high yields, short reaction time, and environmentally benign methods are advantages of this protocol. The catalyst was readily separated by simple filtration and reusable without significant loss of its catalytic efficiency.

Preparation and characterization of isatin complexed with Cu supported on 4-(aminomethyl) benzoic acid-functionalized Fe3O4 nanoparticles as a novel magnetic catalyst for the Ullmann coupling reaction

Isatin complexed with Cu supported on 4-(aminomethyl) benzoic acid-functionalized Fe3O4 nanoparticles (Cu-IS-AMBA-MNPs) as a new catalyst was designed, prepared and characterized by appropriate analyses. The heterogeneous reusable catalyst was successfully used for the efficient and widespread syntheses of diaryl ethers and diarylamines via the Ullmann coupling reaction. This green catalyst was easily removed, reused several times with no significant loss of its activity, and provided a clean synthesis with excellent yield and reduced time.

A diaryl ether compounds of the novel preparation method and application thereof

The invention relates to a diaryl ether compounds of the novel preparation method, in particular compound is added to the reactor in sequence 1, dimethyl sulfoxide, cesium carbonate, compound 2, stirring at room temperature 10 - 60 minutes; then placing the reaction temperature is set to 70 - 120 °C the pot of the oil bath, and incandescent lamp for irradiation, the course of the reaction by TLC detection, to be after the reaction, the reaction solution by filtration, extraction and column chromatography, to obtain the target compound, the completion of the diaryl ether compound preparation. The technical scheme of the present invention visible under light induction, does not add any transition metal catalyst and ligand firmly oxidation reducing agent, aryl halide with phenol derivatives in photocatalytic C - O cross-coupling reaction. Preparation of mild conditions, green, high efficiency, low cost, simple and convenient operation. The preparation of this compound is a biological, medical, in the field of organic synthesis in particular pharmaceutical synthesis of important synthetic intermediate.